Principal Investigators

    Zaal Kokaia


    Lund University

    Contact information of lead PI



    Title of project or programme

    Stem cell therapy for stroke and other neurodegenerative diseases

    Source of funding information

    Swedish Research Council

    Total sum awarded (Euro)

    € 652,884

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Parkinson's disease & PD-related disorders


    Research Abstract

    Background: We have previously shown restoration of function in damaged human brain by neural transplantation. Also that human neural stem cells survive transplantation and improve deficits in the stroke-damaged rodent brain, and that the adult brain tries to repair itself after stroke by producing new neurons from its own neural stem cells. Objectives: (1) To develop new strategies to repair the brain and improve functional recovery after stroke by neuronal replacement from endogenous or grafted neural stem/progenitor cells or reprogrammed somatic cells; (2) To determine and optimize the actions of inflammation and immune cells on neurogenesis from grafted and endogenous cells and on the functional restoration after stroke; (3) To continue to develop a clinically effective cell replacement therapy in Parkinson?s disease using stem cell-derived dopamine neurons. Methods: (i) In vitro systems for neural stem/progenitor cells; (ii) Cell sorting and transplantation techniques; (iii) Disease models in rats and mice; (iv) Gene transfer techniques and transgenic mice; (v) Microarray; (vi) Immunocytochemistry, stereology and anatomical tracing; (vii) Electron microscopy; (viii) Patch-clamp technique; (ix) Behavioral test battery; (x) Clinical assessment of patients, MRI and PET imaging. Significance: This translational research may lead to novel therapeutic strategies to restore and preserve function in human neurodegenerative disorders.

    Lay Summary

    Further information available at:

Types: Investments > €500k
Member States: Sweden
Diseases: Parkinson's disease & PD-related disorders
Years: 2016
Database Categories: N/A
Database Tags: N/A

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