Principal Investigators

    V.Baekelandt, R.Melki, M.Heneka, S.Hunot



    Contact information of lead PI



    Title of project or programme

    SYNACTION: Unravelling the pathophysiological role of alpha-synuclein aggregation, transmission and neuroinflammation in neurodegeneration

    Source of funding information


    Total sum awarded (Euro)

    € 948,291

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Parkinson's disease and PD-related disorders|Alzheimer's disease & other dementias


    Research Abstract

    Several neurodegenerative disorders, including Parkinson?s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA) are caused by aggregates of a single protein, known as alpha-synuclein, in different brain regions and cell types.

    For a long time, researchers have been puzzled by how a single protein can be involved in these different di- seases. Now, recent intriguing findings by our consortium (Peelaerts et al. 2015, Nature) propose that the shape of the alpha-synuclein aggregates might explain this clinical heterogeneity. Moreover, these diseases are accompanied by different neuroinflammation profiles in humans and in animal models.

    In this project, we will use alpha-synuclein aggregates from human brain samples of PD, DLB and MSA pa- tients and study their pathological and inflammatory effects in advanced experimental rodent and non- human primate models. These new insights will contribute to early diagnosis, prevention and the develop- ment of novel therapeutic strategies for alpha-synuclein-related disorders

    Lay Summary

    Further information available at:

Types: Investments > €500k, JPND Projects
Member States: Belgium, France, Germany, JPND
Diseases: Alzheimer's disease & other dementias, Parkinson's disease & PD-related disorders
Years: 2016
Database Categories: N/A
Database Tags: N/A

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