V.Baekelandt, R.Melki, M.Heneka, S.Hunot
SYNACTION: Unravelling the pathophysiological role of alpha-synuclein aggregation, transmission and neuroinflammation in neurodegeneration
Parkinson's disease and PD-related disorders|Alzheimer's disease & other dementias
Several neurodegenerative disorders, including Parkinson?s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA) are caused by aggregates of a single protein, known as alpha-synuclein, in different brain regions and cell types.
For a long time, researchers have been puzzled by how a single protein can be involved in these different di- seases. Now, recent intriguing findings by our consortium (Peelaerts et al. 2015, Nature) propose that the shape of the alpha-synuclein aggregates might explain this clinical heterogeneity. Moreover, these diseases are accompanied by different neuroinflammation profiles in humans and in animal models.
In this project, we will use alpha-synuclein aggregates from human brain samples of PD, DLB and MSA pa- tients and study their pathological and inflammatory effects in advanced experimental rodent and non- human primate models. These new insights will contribute to early diagnosis, prevention and the develop- ment of novel therapeutic strategies for alpha-synuclein-related disorders