Principal Investigators

    Castren Eero


    University of Helsinki

    Contact information of lead PI



    Title of project or programme

    Synaptic circuit protection in AD and HD: BDNF/TrkB and Arc signaling as rescue factors

    Source of funding information

    Academy of Finland

    Total sum awarded (Euro)

    € 288,180

    Start date of award


    Total duration of award in years



    Research Abstract

    Synaptic plasticity control by brain-derived neurotrophic factor (BDNF) through TrkB receptor signaling is a fundamental characteristic of all neuronal networks in the brain. The major neurodegenerative disorders, Huntington ´s disease and Alzheimer ´s disease, are both strongly associated with defects in BDNF/TrkB signaling. This project investigates drugs that enhance BDNF availability and ameliorate TrkB signaling, and when combined with physical exercise, are highly efficient protective factors for both diseases and thus represent an innovative therapeutic avenue promising high patient benefits.

    Further information available at:

Types: Investments < €500k
Member States: Finland
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

Export as PDF