University of Helsinki
Synaptic circuit protection in AD and HD: BDNF/TrkB and Arc signaling as rescue factors
Academy of Finland
Synaptic plasticity control by brain-derived neurotrophic factor (BDNF) through TrkB receptor signaling is a fundamental characteristic of all neuronal networks in the brain. The major neurodegenerative disorders, Huntington ´s disease and Alzheimer ´s disease, are both strongly associated with defects in BDNF/TrkB signaling. This project investigates drugs that enhance BDNF availability and ameliorate TrkB signaling, and when combined with physical exercise, are highly efficient protective factors for both diseases and thus represent an innovative therapeutic avenue promising high patient benefits.