Principal Investigators


Castren Eero

Institution


University of Helsinki

Contact information of lead PI


Country


Finland

Title of project or programme


Synaptic circuit protection in AD and HD: BDNF/TrkB and Arc signaling as rescue factors

Source of funding information


Academy of Finland

Total sum awarded (Euro)


€ 288,180

Start date of award


01/01/2016

Total duration of award in years


3.3

Keywords


Research Abstract


Synaptic plasticity control by brain-derived neurotrophic factor (BDNF) through TrkB receptor signaling is a fundamental characteristic of all neuronal networks in the brain. The major neurodegenerative disorders, Huntington ´s disease and Alzheimer ´s disease, are both strongly associated with defects in BDNF/TrkB signaling. This project investigates drugs that enhance BDNF availability and ameliorate TrkB signaling, and when combined with physical exercise, are highly efficient protective factors for both diseases and thus represent an innovative therapeutic avenue promising high patient benefits.

Further information available at:


https://www.neurodegenerationresearch.eu/wp-content/uploads/2015/10/Factsheet_CircProt-1.pdf

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