Principal Investigators

    McShane, Rupert


    University of Oxford

    Contact information of lead PI


    United Kingdom

    Title of project or programme

    Systematic reviews of interventions which target modifiable risk factors for dementia

    Source of funding information


    Total sum awarded (Euro)

    € 378,108

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease and other dementias


    Research Abstract

    The last 200 years have seen a hugely successful effort by the world’s economies to change the main risk factor for dementia: the age at which we die. Unfortunately, this has been in the wrong direction and one in three of us now die suffering from dementia. The societal costs are huge. Less pessimistically, the age-specific prevalence of dementia has recently been shown to have declined in the UK from 8.3% to 6.5% of those over 65 years over the last 20 years. This substantial change, shown by the robust MRC Cognitive Function and Ageing Study, suggests that there may be risk factors which can be modified. Obvious candidates include diet, education and vascular risk factors (blood pressure, smoking, cholesterol, diabetes and exercise). Some risk factors may be more dementia-specific, averting or slowing symptom progression in prodromal disease. We all have a personal stake in knowing whether interventions which alter these putative risks will reduce our chances of dementia.

    Lay Summary

    Further information available at:

Types: Investments > €500k
Member States: United Kingdom
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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