Principal Investigators


David Klenerman

Institution


University of Cambridge

Contact information of lead PI


Country


United Kingdom

Title of project or programme


Testing a new diagnostic tool for Alzheimer's disease and Dementia with Lewy Bodies

Source of funding information


Alzheimer's Research UK

Total sum awarded (Euro)


€ 67,639

Start date of award


01/01/2016

Total duration of award in years


1.3

Keywords


Research Abstract


Protein aggregates are thought to play a key role in the development of Alzheimer’s disease but are difficult to detect since they are present at low concentrations and different structures. We have developed a method to directly detect image protein aggregates when they form a particularly damaging structure and shown that this method works in the CSF of patients allowing us to count the number and size present. This is a very exciting result and we now want to further develop this method and then do a pilot study to see if it can detect differences between patients with Alzheimer’s disease from normal people.  This may allow the early diagnosis of the disease and monitoring of therapies.

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