Name of Resource

    TgF344-AD (University College Cork)

    Name of Principal Investigator - Title

    Dr

    Name of Principal Investigator - First name

    Mark

    Name of Principal Investigator - Last name

    Rae

    Address of institution -Institution

    University College Cork

    Address of institution - Street address

    Department of Physiology, Western Gateway Building

    Address of institution - City

    Cork

    Address of institution - Postcode

    Country

    Ireland

    Website
    Contact email
    Summary

    Rat model of AD (TgF344-AD), which expresses the mutant human transgenes: amyloid precursor protein (APPsw) and presenilin 1 (PS1ΔE9).

    Q1a. Please indicate below if your cohort includes or expects to include, incidence of the following conditions? (1)

    Alzheimer's disease & other dementias

    Q1b. Does your resource hold

    Animals

    Q2a. Does the resource act as a centre for access and distribution to external groups (who are not the Principal Investigators (PI) for the resource)?

    Yes

    Q2b. If Yes, what procedures and rules apply for access?

    Apply to PI or co-ordinator at resource| Access through collaboration with PI only| National access| International Access| Applicant needs to provide separate external ethics approval| Other requirements exist

    Q3a. Does your resource develop experimental models (animal/cell) for external groups?

    No

    Q3b. If YES and your resource is related to an ANIMAL model, what types of models are provided?

    Wild type| Genetically Modified

    Q3c. If YES and your resource is related to a CELL model, what types of models are provided?

    Q4a. Is this activity supported as:

    Independent of collaboration

    Q4b. Do you deposit what you supply in any kind of central repository?

    No

    Disease

    AD

    Species

    Rat

    Available to external user

    Yes, but with specifications

    Full phenotypic character

    F344 rat expressing PS1 (delta E9) and APPswe mutations

    Please indicate the phenotypes

    See Cohen et al., (2013). J. Neurosci. 33(15), 6245

    List of genotypes or other subtypes

    Q5b. Cognitive function, No of models

    Q5b. Cognitive function, Available to external users

    Q5b. Cognitive function, Full phenotypic characterisation

    Q5b. Cognitive function, Nature of phenotype

    Q5b. Motor function, No of models

    Q5b. Motor function, Available to external users

    Q5b. Motor function, Full phenotypic characterisation

    Q5b. Motor function, Nature of phenotype

    Q5b. Physiological function, no of models

    Q5b. Physiological function, Available to external users

    Q5b. Physiological function, Full phenotypic characterisation

    Q5b. Physiological function, Nature of phenotype

    Q5b. Other function (please specify), no of models

    Please specify other function

    Q5b. Other function (please specify), Available to external users

    Q5b. Other function (please specify), Full phenotypic characterisation

    Q5b. Other function (please specify), Nature of phenotype

    Q6. Please indicate if your resource is already linked into European or international consortia or networks?

    EBiSC| StemBANCC

    Q7a. Is maintenance of this resource dependent on continued funding?

    Yes

    Q7b. If yes, when does the current funding period end?

    2017

    Q7c. What is the expected lifespan of the resource (in years)?

    Indefinite, if storage funded

    Q7d. Are there other plans affecting future use that it may be useful to know?

    StemBANCC sustaininability award application

Types: Experimental Models
Member States: Ireland
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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