Title of the cohort

The Cambridge City over-75s Cohort Study

Acronym for cohort


Name of Principal Investigator
First nameCarol
Last nameBrayne
Address of institution where award is held
InstitutionInstitute of Public Health, University of Cambridge
Street AddressRobinson Way
PostcodeCB2 0SR
  • United Kingdom


Contact email
1. The cohort includes, or expects to include, incidence of the following conditions
  • Alzheimer’s disease and other dementias
  • Neurodegenerative disease in general
When studies on the above condition(s) are expected to become possible
  • Already possible
2a. Stated aim of the cohort

CC75C is a long-term follow-up study of a representative population-based sample of older people which started in 1985 from a survey of over 2,600 men and women aged 75 and above

2b. Features distinguishing this cohort from other population cohorts
3a. i) Number of publications that involve use of cohort to date


3a. ii) Up to three examples of studies to date (PI, Institution, Title of Study)
3b. Publication list/link to where data or publications are accessible (if available)


3c. Information (i.e. research findings) expected to be gained from the population cohort
4a. Study criteria: age range of participants at recruitment
Age in years from:
To (‘until death’ if applicable):no limit
4b. Study criteria: inclusion criteria
4c. Study criteria: exclusion criteria


5. Size of the cohort (i.e. number of participants enrolled)
  • 1,000 – 5,000 participants
6a. Measures used to characterise participants

The core data set comprises data collected from the main surveys to date using the CC75C structured schedule administered by trained interviewers. This provides longitudinal data on socio-demographic variables (e.g. place of residence, household structure, marital status and social contact), activities of daily living, use of health and social service, health problems and medication. The interview schedule has undergone slight revisions over the years with the addition of new sections, such as questions on service use added in Survey 3, but maintaining continuity of core measures has remained a priority. The CC75C study also holds other data resources collected at different periods in the study to examine specific topics of importance in ageing research.

6b. Additional measures for participants with a clinical disorder
6c. Are there defined primary and secondary endpoints (e.g. defined health parameters)
  • No
7. Study design
  • Longitudinal
  • Prospective cohort
8. Cases matched by

Other health assessment (specify) / N/A

9a. Does the study include a specialised subset of control participants
  • No
9b. If yes, description of specialised subset of control participants
10a. i) Data collection start date


10a. ii) Data collection end date
10a iii) Data collection for this study is
  • Data collection ongoing
10b. Plans to continue the cohort study beyond the current projected end date
  • Yes – funding applied for
11. Data collected
  • Only through the study
12. System in place to enable re-contact with patients for future studies
  • Yes (participants have given permission to be re-contacted via the PIs to ask if they would participate in further studies)
13a. Format and availability of data stored in a database
Yes/No% available
Data summarised in database
Database is web-based
Database on spreadsheet Yes, in STATA
Database is on paper
Other (specify)
Language used:
13b. Format and availability of data held as individual records
Yes/No% available
Data held as individual records Yes
Data is web-based
Data held on computer based records Yes
Data held on cards
Other (specify)


Language used:
14a. Are data available to other groups


14b. Access policy/mechanisms for access if data are available to other groups
  • Apply to PI or co-ordinator at resource
  • Access Committee mechanism
15. Data sharing policy specified as a condition of use
  • Data made publicly available after a specified time point
16a. Are tissues/samples/DNA available to other groups


16b. i) Description of available tissues/samples/DNA
  • Living donors:blood
  • Post-mortem donors: brain
16b. ii) Form available tissues/samples/DNA are supplied in
  • Primary Samples: Stabilised samples (frozen or fixed)
  • Secondary samples: plasma
  • Secondary samples: DNA
  • Secondary samples: RNA
  • Secondary samples: protein extracts
16b. iii) Is the access policy/mechanism for obtaining samples the same as that for obtaining data


17. Is information on biological characteristics available to other groups

    Types: Population Cohorts
    Member States: United Kingdom
    Diseases: Alzheimer's disease & other dementias, Neurodegenerative disease in general
    Years: 2011
    Database Categories: N/A
    Database Tags: N/A

    Export as PDF