Title of the cohort

The Cardiovascular Risk Factors, Aging, and Dementia Study

Acronym for cohort


Name of Principal Investigator
TitleMD, PhD, Associate Professor
First nameMiia
Last nameKivipelto
Address of institution where award is held
InstitutionAging Research Center, Karolinska Institutet
Street Address
Postcode113 30
  • Sweden


Contact email
Funding source

1) Swedish Research Council (VR)
2) Academy of Finland
3) Alzheimer Association
4) Novo-Nordisk

1. The cohort includes, or expects to include, incidence of the following conditions
  • Alzheimer’s disease and other dementias
  • Neurodegenerative disease in general
When studies on the above condition(s) are expected to become possible
  • Already possible
2a. Stated aim of the cohort

To investiagte cardiovascular and lifestyle related risk factors for cognitive impairment and dementia

2b. Features distinguishing this cohort from other population cohorts

Data available already from midlife and follow-up time over 30 years

3a. i) Number of publications that involve use of cohort to date


3b. Publication list/link to where data or publications are accessible (if available)
3c. Information (i.e. research findings) expected to be gained from the population cohort
4a. Study criteria: age range of participants at recruitment
Age in years from:65
To (‘until death’ if applicable):79
4b. Study criteria: inclusion criteria

Differential diagnoses for dementing disorders including brain MRI, CSF, ECG, blood tests and more detailed neuropsyvhological evaluation

4c. Study criteria: exclusion criteria


5. Size of the cohort (i.e. number of participants enrolled)
  • 1,000 – 5,000 participants
6a. Measures used to characterise participants

Cognitive tests, health and life-style questionnary, physcial examination, and blood samples

6b. Additional measures for participants with a clinical disorder

Mild cognitive impairment, dementia, Alzheimer’s disease

6c. Are there defined primary and secondary endpoints (e.g. defined health parameters)

Cognitive impairment, mild cognitive impairment, dementia and Alzheimer’s disease

7. Study design
  • Prospective cohort
8. Cases matched by
  • Age
  • Sex
  • Other health assessment (specify) / N/A
    • We have used a reprentative population based sample. In some sub-studies, i.e. MRI we have used case-control design
9a. Does the study include a specialised subset of control participants
  • No
9b. If yes, description of specialised subset of control participants
10a. i) Data collection start date


10a. ii) Data collection end date
10a iii) Data collection for this study is
  • Data analysis ongoing
10b. Plans to continue the cohort study beyond the current projected end date
  • Yes – intend to apply for funding
11. Data collected
  • Only through the study
  • Through links to medical records
12. System in place to enable re-contact with patients for future studies
  • Yes (participants have given permission to be re-contacted via the PIs to ask if they would participate in further studies)
13a. Format and availability of data stored in a database
Yes/No% available
Data summarised in database yes 95
Database is web-based no
Database on spreadsheet yes
Database is on paper yes
Other (specify)


Language used:


13b. Format and availability of data held as individual records
Language used:
14a. Are data available to other groups


14b. Access policy/mechanisms for access if data are available to other groups
  • Access through collaboration with PI only
15. Data sharing policy specified as a condition of use
  • No requirement to make data publicly available
16a. Are tissues/samples/DNA available to other groups


16b. i) Description of available tissues/samples/DNA
  • Living donors:blood
  • Living donors: DNA
  • Living donors: cerebro-spinal fluid
16b. ii) Form available tissues/samples/DNA are supplied in
16b. iii) Is the access policy/mechanism for obtaining samples the same as that for obtaining data


17. Is information on biological characteristics available to other groups
  • Yes, for all the cohort

    Types: Population Cohorts
    Member States: Sweden
    Diseases: Alzheimer's disease & other dementias, Neurodegenerative disease in general
    Years: 2011
    Database Categories: N/A
    Database Tags: N/A

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