Principal Investigators

    Hamel, Edith


    McGill University

    Contact information of lead PI



    Title of project or programme

    The cellular basis of neurovascular coupling in the cerebral cortex.

    Source of funding information


    Total sum awarded (Euro)

    € 501,861

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    Research Abstract

    Blood supply to the brain is highly regulated and is distributed where neurons are active at performing a task. This control is so precise that it is used to map neuronal activity in brain imaging techniques under both health and disease conditions. However, how the brain can direct blood to the active neurons is still poorly understood and, particularly, in disease conditions when the dialogue between neurons and blood vessels is jeopardized. Our work will focus on the cerebral cortex, a region important in attention, cognition, perception and many other functions. We will study the role of specific groups of neurons within the cortex, and we will evaluate how modulating cortical activity acutely or chronically like in disease conditions will affect this tight coupling between blood supply and neuronal activity. Our findings should help understand and interpret normal and pathological brain imaging data, and show how diseases, such as Alzheimer’s disease, can alter the dialogue between neurons and blood vessels.

    Lay Summary

    Further information available at:

Types: Investments > €500k
Member States: Canada
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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