Name of resource

The Harwell Frozen embryo and sperm archive (FESA)

Name of Principal Investigator
First nameMartin
Last nameFray
Address of institution where award is held
InstitutionMRC Harwell
Street AddressHarwell Science and Innovation Campus
PostcodeOX11 0RD
  • United Kingdom
  • Website
    Contact email

    The MRC’s frozen embryo and sperm archive holds a collection of mouse models of human disease that are distributed to the wider scientific community. We also hold some mouse models that have been frozen for our own researchers that are not available to the community.

    1a. The resource holds animal models relevant to the study of the following neurodegenerative diseases
  • Motor neurone diseases
  • Prion disease
  • Huntington’s disease
  • Neurodegenerative disease in general
  • Parkinson’s disease
  • Spinocerebellar ataxia (SCA)
  • Spinal muscular atrophy (SMA)
  • 1b. The resource holds:
  • Animals
  • Frozen embryos
  • Frozen sperm
  • 2a. The resource acts as a centre for access and distribution to external groups (who are not the PIs of the resource)
    2b. Procedures and rules for access
  • Access independent of collaboration with PI
  • Local/ regional access
  • National access
  • International access
  • Access to industry
  • Charge for retrieval
  • 3a. Does the resource develop animal models for external groups


    3b. Types of models provided
  • Not applicable
  • 4a This activity is supported as:
  • Independent of collaboration
  • 4b. The supplied material deposited in a central repository


    5a Disease models available
    DiseaseSpeciesAvailable to external user (Y/N)Full phenotypic character (Y/N or partial)PhenotypesGenotypes or other subtypes
    HDMouseNPartialShort life span/tremorsHets
    PrionMouseYYSuceptibility to diseaseHets/Homs
    PDMouseYPartialOlfactory memory and motor controlHet
    MNDMouseYYMice show dystrophic changes in mucscle histopathologyHets/Homs
    5b. Other models/phenotypes available through the resource relevant to neurodegenerative conditions
    No. of modelsAvailable to external usersFull phenotypic characterisation available (Y/N or partial)Nature of phenotype
    Low grip strength3YPartial
    2YPartialMemory deficit
    2YPartialMuscle tremors
    NumerousYPartialVarious phenotypes
    6. European or international consortia or networks to which the resource is linked
    Jackson Laboratories, USAInternational mouse knockout consortium
    European Mutant Mouse Archive
    International Mouse Knockout Consortium
    7a. Maintenance of the resource is dependent on continued funding


    7b. End date of current funding period


    7c. Expected lifespan of the resource (in years)


    7d. Other plans affecting future use

    FESA is a core funded MRC resource but it is also supported in part by the funds we receive from the EU through our membership of the EMMA consortium. The current EMMA grant will come to an end Dec 2012.

      Types: Experimental Models
      Member States: United Kingdom
      Diseases: Huntington's disease, Motor neurone diseases, Neurodegenerative disease in general, Parkinson's disease & PD-related disorders, Prion disease, Spinal muscular atrophy (SMA), Spinocerebellar ataxia (SCA)
      Years: 2011
      Database Categories: N/A
      Database Tags: N/A

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