Name of Fellow

    Diana Filipa Ferreira da Silva




    Contact information of fellow



    Title of project/programme

    The PARL-PGAM5-PINK1 axis on mitochondrial homeostasis: implications for Parkinson´s disease.

    Source of funding information


    Total sum awarded (Euro)

    € 116,640

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Parkinson's disease & PD-related disorders


    Research Abstract

    24 million people suffer from neurodegenerative disease and these numbers will double in the next 20 years. Due to their unique metabolism, neurons rely extensively on mitochondria for energy production. Failure of mitochondrial function is connected to Parkinson´s disease (PD) and mutations in genes affecting mitochondria, PINK1 and Parkin, cause PD. PINK1, a mitochondrial kinase, is key for normal activity of mitochondria. PINK1 is under control of proteolitic cleaveage by PARL and phosphatase activity by PGAM5. Here I propose to use two complementary systems to study the regulatory processes of PARL and PGAM5. I will capitalize on the power of Drosophila genetics to discover novel partners regulating PARL-and PGAM5-dependent activity towards PINK1 and I will use primary cortical neurons and patient-derived cybrids to evaluate the evolutionary conservation of the mechanisms I discovered. My work will unveil key regulatory events controlling mitochondrial function relevant to the molecular events that underlie PD.

Types: Fellowships
Member States: Portugal
Diseases: Parkinson's disease & PD-related disorders
Years: 2016
Database Categories: N/A
Database Tags: N/A

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