Principal Investigators


A/Pr Giuseppe Verdile

Institution


Curtin University of Technology

Contact information of lead PI


Country


Australia

Title of project or programme


The role of a presenilin 2 truncation (PS2V) in Alzheimer's Disease

Source of funding information


National Health and Medical Research Council

Total sum awarded (Euro)


€ 370,198

Start date of award


01/01/2014

Total duration of award in years


4

Keywords


Research Abstract


The Presenilin and APP proteins are centrally important in inherited, early onset Alzheimer’s disease. We have discovered that a shortened form of Presenilin protein, “PS2V”, appears to increase specifically the rate at which the APP protein is cleaved to produce the “Amyloid beta” protein fragment that is found in Alzheimer’s disease brains. This occurs when brain cells are under oxidative stress. Understanding this process will facilitate development of appropriate therapeutic strategies for the disease.

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