Principal Investigators

    A/Pr Giuseppe Verdile


    Curtin University of Technology

    Contact information of lead PI



    Title of project or programme

    The role of a presenilin 2 truncation (PS2V) in Alzheimer's Disease

    Source of funding information

    National Health and Medical Research Council

    Total sum awarded (Euro)

    € 370,198

    Start date of award


    Total duration of award in years



    Research Abstract

    The Presenilin and APP proteins are centrally important in inherited, early onset Alzheimer’s disease. We have discovered that a shortened form of Presenilin protein, “PS2V”, appears to increase specifically the rate at which the APP protein is cleaved to produce the “Amyloid beta” protein fragment that is found in Alzheimer’s disease brains. This occurs when brain cells are under oxidative stress. Understanding this process will facilitate development of appropriate therapeutic strategies for the disease.

    Further information available at:

Types: Investments < €500k
Member States: Australia
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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