Name of Fellow

    Dr Mark Greenough

    Institution

    Funder

    NHMRC

    Contact information of fellow

    Country

    Australia

    Title of project/programme

    The role of copper in Ubiquitin-dependent protein degradation in Alzheimer's disease

    Source of funding information

    NHMRC

    Total sum awarded (Euro)

    € 399,335

    Start date of award

    01/01/16

    Total duration of award in years

    4.0

    The project/programme is most relevant to:

    Alzheimer's disease & other dementias

    Keywords

    alzheimer disease | amyloid precursor protein | protein degradation | ubiquitination | copper deficiency

    Research Abstract

    Ubiquitin’s are small proteins that tag other proteins in a process known as “Ubiquitination”. Often this is to target them for degradation once they are no longer needed i.e. to take out the rubbish. This process is disrupted in Alzheimer’s disease (AD), which may contribute to the disease. This project aims to find out if copper, an essential metal for life, is required for this process. Drugs that are designed to deliver copper to brain cells have been effective in small AD clinical trials.

Types: Fellowships
Member States: Australia
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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