Name of Fellow



    European Commission FP7-Seventh Framework Programme

    Contact information of fellow



    Title of project/programme

    The role of neuronal intracellular traffic in Alzheimer´s disease

    Source of funding information

    European Commission FP7-Seventh Framework Programme

    Total sum awarded (Euro)

    € 100,000

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    L302 Cell biology and molecular transport mechanisms |L502 Molecular and cellular neuroscience | | L404 Ageing |

    Research Abstract

    In neurons of Alzheimer’s disease (AD) there is an aberrant accumulation of beta-amyloid (A?) at synapses that renders difficult the formation of new memories for AD patients. Intracellular trafficking abnormalities have been implicated in A? accumulation. This research project aims to define how neuronal intracellular trafficking is mechanistically involved in A? accumulation that leads to AD. We will determine how the intracellular itinerary of the amyloid precursor protein in neurons influences the generation of A?. We will determine the intracellular trafficking of lysosomal hydrolases in neurons and their contribution to the lysosomal clearance of A?. Furthermore, we will investigate the mechanism whereby regulators of intracellular trafficking identified as risk-factors for AD contribute to A? accumulation. Finally, because aging is the most important risk factor for AD, we will determine if alterations in intracellular trafficking occur in aging, identifying a new mechanism of vulnerability to neurodegeneration in AD. Thus, we will demonstrate how intracellular trafficking is implicated in AD and unravel an important disease mechanism.

Types: Fellowships
Member States: N/A
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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