Principal Investigators

    doc. Ing. Karel Holada, Ph.D.


    Charles University in Prague, First Faculty of Medicine

    Contact information of lead PI


    Czech Republic

    Title of project or programme

    The role of proteinase-activated receptors in pathogenesis of prion diseases

    Source of funding information

    Czech Science Foundation

    Total sum awarded (Euro)

    € 475,704

    Start date of award


    Total duration of award in years



    Research Abstract

    Transmissible spongiform encephalopathies (TSEs) or prion diseases are fatal neurodegenerative disorders of men and animals. The hallmark of TSEs is accumulation of misfolded form of prion protein in the brain of affected subjects. Despite intensive research the mechanism of neurodegeneration in TSEs remains unknown and no specific treatment is available. Proteinase-activated receptors (PARs) facilitate cellular responses to extracellular proteases. Recent studies provided strong evidence about the involvement of PARs in the pathogenesis of other neurodegenerative proteinopathies, like Alzheimer and Parkinson disease. In contrast, the role of PARs in TSEs has not been studied yet. To prove the involvement of PARs in TSE pathogenesis, we plan to utilize variety of models including PAR-1 and PAR-2 knockout mice. Studies will be conducted on prion infected cell cultures, on mouse TSE models in vivo and also on autoptic CNS tissues of TSE patients. We anticipate that our project will provide essential information about the feasibility of PARs targeting as a therapeutic approach in TSEs.

    Further information available at:

Types: Investments < €500k
Member States: Czech Republic
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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