Principal Investigators

    Song, Weihong


    University of British Columbia

    Contact information of lead PI



    Title of project or programme

    The role of RCAN1 in Alzheimer pathogenesis

    Source of funding information


    Total sum awarded (Euro)

    € 594,750

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    Research Abstract

    Alzheimer’s disease (AD) is the most common neurodegenerative disorder leading to dementia in the elderly population. Patients with diabetes have a greater risk to develop AD and a majority of AD patients also have hyperglycemia. The mechanism linking diabetes to AD remains undefined. Progressive neuronal loss is one of the pathological features of AD. People with Down Syndrome having extra copy of chromosome 21 develop characteristic AD neuropathology after middle age and several genes on chromosome 21 including APP and the regulator of calcineurin 1 (RCAN1) are implicated in AD pathogenesis. Our preliminary studies suggest that RCAN1 promotes neurodegeneration and our working hypothesis is that abnormal RCAN1 expression and function contribute to Alzheimer pathogenesis. This proposal seeks to elucidate the molecular mechanism of RCAN1’s effect on Alzheimer pathogenesis and define its role in linking diabetes to AD. The results will be of clinical significance and provide evidences for targeting RCAN1 in AD treatment.

    Lay Summary

    Further information available at:

Types: Investments > €500k
Member States: Canada
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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