Principal Investigators

    Robertson, Janice


    University of Toronto

    Contact information of lead PI



    Title of project or programme

    The TAR DNA-Binding Protein (TDP-43) and Amyotrophic Lateral Sclerosis

    Source of funding information


    Total sum awarded (Euro)

    € 623,387

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Motor neurone diseases


    Research Abstract

    Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two devastating neurodegenerative diseases that share a number of commonalities. One major commonality is the presence of abnormal accumulations of a protein called TDP-43 in the brain and spinal cord of affected individuals. We are trying to understand how these abnormalities of TDP-43 occur and how they contribute to the disease process. We have already made major strides through the development of new disease models and use of cutting edge technologies to uncover an important disease pathway that links not only ALS and FTD, but also Alzheimer’s and Parkinson’s disease. Through further investigation we hope to establish this link with the aim of gaining a fuller understanding of the mechanistic basis of how TDP-43 is related to disease causation. It is through this that we hope to develop effective treatments.

    Lay Summary

    Further information available at:

Types: Investments > €500k
Member States: Canada
Diseases: Motor neurone diseases
Years: 2016
Database Categories: N/A
Database Tags: N/A

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