Principal Investigators

    Marija Cvijovic


    University of Gothenburg

    Contact information of lead PI



    Title of project or programme

    Theoretical and empirical aspects of aging and rejuvenation

    Source of funding information

    Swedish Foundation for Strategic Research

    Total sum awarded (Euro)

    € 652,884

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    Research Abstract

    Ageing is by far the biggest risk factor for a wide range of prevalent clinical conditions caused by accumulated aggregated proteins. My research focus is on the development of novel mathematical models to deeper understand aging and age associated molecular processes as well as their implications on age-dependent diseases. To investigate mechanism of this process and the nature of aggregate inheritance we are developing models on both single–cell and population level. Models are based on the Ordinary Differential Equations and abstract representation of the cell-to-cell variability in the hierarchical model structure. A stochastic model will be developed to assess the nature of aggregate inheritance. A web-based platform will be established containing database for storing simulation and experimental data, model simulator and visualization tool that allow descriptive representation and interpretation of the results. The project will generate novel insights into the understanding of age-related disorders, especially those associated to aggregate accumulation like Alzheimer’s disease. Preliminary results showed that the combination of a single-cell model and a simulation platform permitting parallel composition and dynamic node creation is an efficient tool for exploration of cell behavior.

    Lay Summary

    Further information available at:

Types: Investments > €500k
Member States: Sweden
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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