Title of project or programme
Title of PIDonepezil and memantine in moderate to severe Alzheimer’s disease – The DOMINO-AD Trial
Principal Investigators of project/programme grant
ProfessorRobertHowardKing’s College LondonUK
Address of institution of lead PI
InstitutionKing’s College London
Street AddressStrand
PostcodeWC2R 2LS
  • United Kingdom
Source of funding information

Medical Research Council

Total sum awarded (Euro)


Start date of award


Total duration of award in months


The project/programme is most relevant to
  • Alzheimer’s disease and other dementias
Research abstract in English

This RCT will examine efficacy of drug treatments for dementia (cholinesterase inhibitors and memantine), singly and in combination, over 12 months, in 800 Alzheimer s disease (AD)patients who are already treated with a cholinesterase inhibitor but have declined to reach the transition point to moderate to severe disease. Primary outcome measures will be cognitive function, activities of daily living and cost effectiveness. Secondary outcome measures will include quality of life, institutionalisation and family carer burden. The Trial has been designed to answer questions about the treatment of patients who are representative of those seen in clinical practice in terms of outcomes that have relevance to patients, carers and society.

Lay Summary
In which category does this research fall?
  • Clinical research

    Types: Investments > €500k
    Member States: United Kingdom
    Diseases: Alzheimer's disease & other dementias
    Years: 2011
    Database Categories: N/A
    Database Tags: N/A

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