Principal Investigators

    Maria Eriksdotter


    Karolinska Institute

    Contact information of lead PI



    Title of project or programme

    Towards Neurotrophic therapes in Alzheimer's disease

    Source of funding information

    The Swedish Brain Foundation

    Total sum awarded (Euro)

    € 108,814

    Start date of award


    Total duration of award in years



    Research Abstract

    The overall goal of this program is to explore novel ways to target key pathological mechanisms in AD by direct central nervous system (CNS) targeting regenerative growth
    factor signaling, using both local delivery of the two growth factors NGF and BDNF as well as small-molecule allosteric modulators of growth factor signaling aiming at improving
    cognitive function. Leveraging the functional selectivity of allosteric modulators of NGF and BDNF provides a potential opportunity to develop agents that selectively target NGF and
    BDNF signaling pathways and transportation. The concept will be investigated by cell and animal models. The project brings together a multidisciplinary team of scientists from different disciplines and the necessary resources and models to move novel findings towards clinical translation.

    Further information available at:

Types: Investments < €500k
Member States: Sweden
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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