Dr Rajesh Ghai
Towards Targeting The Endosome In Neurodegenerative Disease
Alzheimer's disease & other dementias
x-ray crystallography | endosomes | membrane trafficking | molecular basis of disease | molecular neuroscience
Mutations and dysregulation of the SNX27-retromer protein platform are strongly linked to Alzheimers disease (AD) and Parkinsons disease (PD). This research program will determine how SNX27-retromer interacts with key molecules associated with AD and PD, the outcomes of which be significantly improved understanding of how mutations in these proteins cause disease, and a necessary molecular framework for future therapeutic targeting.