Name of Fellow


Dr Rajesh Ghai

Institution


Funder


NHMRC

Contact information of fellow


Country


Australia

Title of project/programme


Towards Targeting The Endosome In Neurodegenerative Disease

Source of funding information


NHMRC

Total sum awarded (Euro)


€ 408,396

Start date of award


01/01/16

Total duration of award in years


4.0

The project/programme is most relevant to:


Alzheimer's disease & other dementias

Keywords


x-ray crystallography | endosomes | membrane trafficking | molecular basis of disease | molecular neuroscience

Research Abstract


Mutations and dysregulation of the SNX27-retromer protein platform are strongly linked to Alzheimer’s disease (AD) and Parkinson’s disease (PD). This research program will determine how SNX27-retromer interacts with key molecules associated with AD and PD, the outcomes of which be significantly improved understanding of how mutations in these proteins cause disease, and a necessary molecular framework for future therapeutic targeting.

Export as PDF