Principal Investigators


Prof. Dr. E.J.A. Scherder

Institution


VU University Medical Center

Contact information of lead PI


Country


Netherlands

Title of project or programme


Train the sedentary brain: move smart to reduce the risk of dementia

Source of funding information


ZonMw

Total sum awarded (Euro)


€ 1,265,680

Start date of award


01/11/2014

Total duration of award in years


4.0

The project/programme is most relevant to:


Alzheimer's disease & other dementias

Keywords


Research Abstract


Physical inactivity (PIA) is a critical risk factor for developing dementia. Our multidisciplinary experts consortium will determine how specific exercise protocols can counter the negative effects of PIA on dementia progression. Primary targets are the APOEe4 carriers, people most at risk to develop dementia. The hypothesis is that physical activity (PA) slows cognitive decline and dementia progression. We will test this hypothesis by generating insights into: a) how PIA impairs cognitive functions, b) how PIA interacts with APOEe4 expression, c) which PA protocols are most promising to slow cognitive decline and dementia progression. Experts monitor the implementation aspects of the PA protocols at all stages. We will address this challenging hypothesis using novel approaches that includes preclinical mouse models and diverse clinical PA protocols. A multitude of stakeholders will benefit from the translation of scientific knowledge to slow dementia progression.

Lay Summary


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