Principal Investigators

    Prof. Dr. E.J.A. Scherder


    VU University Medical Center

    Contact information of lead PI



    Title of project or programme

    Train the sedentary brain: move smart to reduce the risk of dementia

    Source of funding information


    Total sum awarded (Euro)

    € 1,265,680

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    Research Abstract

    Physical inactivity (PIA) is a critical risk factor for developing dementia. Our multidisciplinary experts consortium will determine how specific exercise protocols can counter the negative effects of PIA on dementia progression. Primary targets are the APOEe4 carriers, people most at risk to develop dementia. The hypothesis is that physical activity (PA) slows cognitive decline and dementia progression. We will test this hypothesis by generating insights into: a) how PIA impairs cognitive functions, b) how PIA interacts with APOEe4 expression, c) which PA protocols are most promising to slow cognitive decline and dementia progression. Experts monitor the implementation aspects of the PA protocols at all stages. We will address this challenging hypothesis using novel approaches that includes preclinical mouse models and diverse clinical PA protocols. A multitude of stakeholders will benefit from the translation of scientific knowledge to slow dementia progression.

    Lay Summary

    Further information available at:

Types: Investments > €500k
Member States: Netherlands
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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