Name of Fellow


Kanninen Katja

Institution


Funder


Academy of Finland

Contact information of fellow


Country


Finland

Title of project/programme


Transmitophagy: the key to aging and neurodegeneration?

Source of funding information


Academy of Finland

Total sum awarded (Euro)


€ 434,485

Start date of award


01/09/16

Total duration of award in years


5.0

The project/programme is most relevant to:


Alzheimer's disease & other dementias

Keywords


Alzheimer's disease | aging | mitochondria | astrocytes | Nrf2

Research Abstract


The signi?cance of maintaining mitochondrial integrity is underscored by various diseases associated with mitochondrial dysfunction. This research proposal focuses on a recently discovered process of mitochondrial degradation taking place in the central nervous system. We aim to assess the role of astrocytes in degradation of neuron-derived mitochondria in aging and Alzheimer’s disease. A better understanding of the factors involved in this process may in the future lead to improved treatments for neurodegeneration and ways to increase health and longevity.

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