Name of Resource

    TRE-11CGG-GFP (Erasmus MC)

    Name of Principal Investigator - Title

    Prof

    Name of Principal Investigator - First name

    Rob

    Name of Principal Investigator - Last name

    Willemsen

    Address of institution -Institution

    Department of Clinical Genetics, Erasmus MC

    Address of institution - Street address

    Wijtemaweg 80

    Address of institution - City

    Rotterdam

    Address of institution - Postcode

    3015 CN

    Country

    The Netherlands

    Website
    Contact email
    Summary

    Doxycycline inducible mouse model expressing a Fmr1 control size of 11CGGs coupled to EGFP under control of a Tet-On promoter to study FXTAS; see Hukema et al. Cell Cycle 2014 and Hukema et al. Hum Mol Genet 2015

    Q1a. Please indicate below if your cohort includes or expects to include, incidence of the following conditions? (1)

    Neurodegenerative disease in general

    Q1b. Does your resource hold

    Animals| Frozen sperm| Genetic Material (e.g DNA, RAN, vectors)

    Q2a. Does the resource act as a centre for access and distribution to external groups (who are not the Principal Investigators (PI) for the resource)?

    Yes

    Q2b. If Yes, what procedures and rules apply for access?

    Apply to PI or co-ordinator at resource| International access| Other requirements exist

    Q3a. Does your resource develop experimental models (animal/cell) for external groups?

    No

    Q3b. If YES and your resource is related to an ANIMAL model, what types of models are provided?

    Q3c. If YES and your resource is related to a CELL model, what types of models are provided?

    Q4a. Is this activity supported as:

    Q4b. Do you deposit what you supply in any kind of central repository?

    Disease

    Fragile X-associated Tremor/Ataxia Syndrome (FXTAS)

    Species

    Mouse| Mouse| Rat

    Available to external user

    yes, via TTO

    Full phenotypic character

    Partial

    Please indicate the phenotypes

    none

    List of genotypes or other subtypes

    Q5b. Cognitive function, No of models

    Q5b. Cognitive function, Available to external users

    Q5b. Cognitive function, Full phenotypic characterisation

    Q5b. Cognitive function, Nature of phenotype

    Q5b. Motor function, No of models

    Q5b. Motor function, Available to external users

    Q5b. Motor function, Full phenotypic characterisation

    Q5b. Motor function, Nature of phenotype

    Q5b. Physiological function, no of models

    Q5b. Physiological function, Available to external users

    Q5b. Physiological function, Full phenotypic characterisation

    Q5b. Physiological function, Nature of phenotype

    Q5b. Other function (please specify), no of models

    Please specify other function

    Q5b. Other function (please specify), Available to external users

    Q5b. Other function (please specify), Full phenotypic characterisation

    Q5b. Other function (please specify), Nature of phenotype

    Q6. Please indicate if your resource is already linked into European or international consortia or networks?

    Q7a. Is maintenance of this resource dependent on continued funding?

    Q7b. If yes, when does the current funding period end?

    2019

    Q7c. What is the expected lifespan of the resource (in years)?

    2

    Q7d. Are there other plans affecting future use that it may be useful to know?

Types: Experimental Models
Member States: Netherlands
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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