Name of Fellow


Dr. R.C.G. Helmich

Institution


Funder


Hersenstichting | Dutch Brain Foundation

Contact information of fellow


Country


The Netherlands

Title of project/programme


Why Parkinson's tremor has a variable dopaminergic response - cerebral differences between dopa-responsive and dopa-resistant tremor.

Source of funding information


Hersenstichting | Dutch Brain Foundation

Total sum awarded (Euro)


€ 146,616

Start date of award


01/04/14

Total duration of award in years


3.0

The project/programme is most relevant to:


Parkinson's disease & PD-related disorders

Keywords


Parkinson's disease | tremor | fMRI

Research Abstract


Resting tremor is a core symptom of Parkinson’s disease (PD). Unlike other motor symptoms, the response
of tremor to levodopa varies greatly between PD patients. The reason for this variability is unclear, preventing
treatment and development of new therapies. We showed that PD tremor arises from interactions between
the basal ganglia and the cerebello-thalamo-cortical circuit. Here we compare tremor-related activity in these
circuits between PD patients with dopa-responsive and dopa-resistant tremor, using MR spectroscopy and
combined EMG-fMRI, and testing both groups ON and OFF levodopa.

Export as PDF