Name of Fellow

    Dr. R.C.G. Helmich



    Hersenstichting | Dutch Brain Foundation

    Contact information of fellow


    The Netherlands

    Title of project/programme

    Why Parkinson's tremor has a variable dopaminergic response - cerebral differences between dopa-responsive and dopa-resistant tremor.

    Source of funding information

    Hersenstichting | Dutch Brain Foundation

    Total sum awarded (Euro)

    € 146,616

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Parkinson's disease & PD-related disorders


    Parkinson's disease | tremor | fMRI

    Research Abstract

    Resting tremor is a core symptom of Parkinson’s disease (PD). Unlike other motor symptoms, the response
    of tremor to levodopa varies greatly between PD patients. The reason for this variability is unclear, preventing
    treatment and development of new therapies. We showed that PD tremor arises from interactions between
    the basal ganglia and the cerebello-thalamo-cortical circuit. Here we compare tremor-related activity in these
    circuits between PD patients with dopa-responsive and dopa-resistant tremor, using MR spectroscopy and
    combined EMG-fMRI, and testing both groups ON and OFF levodopa.

Types: Fellowships
Member States: Netherlands
Diseases: Parkinson's disease & PD-related disorders
Years: 2016
Database Categories: N/A
Database Tags: N/A

Export as PDF