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The Boyd Orr cohort is an historical cohort study carried out by the University of Bristol School of Social Medicine to investigate the long term impact of childrens diet, growth, living conditions and health on adult cardiovascular disease. It is…
The Busselton Healthy Ageing Study aims to enhance understanding of ageing by relating the clustering and interactions of common chronic conditions in adults to function. Phase I (recruitment) is a cross-sectional community-based prospective cohort study involving 5,107 ‘Baby Boomers’ (born…
BePaiD (Behaviour and Pain in Dementia) is a longitudinal cohort study of 230 people with dementia, aged over 70, admitted to hospital for acute medical illness, and assessed for BPSD and pain at admission and every 4 (+1) days until…
Based at the University of Bristol, the Avon Longitudinal Study of Parents and Children (ALSPAC), also known as Children of the 90s, is a world-leading birth cohort study. Between April 1991 and December 1992 more than 14,000 pregnant women were…
The Hertfordshire Cohort Study comprises a nationally unique study of 3000 men and women born during the period 1931-1939 and still resident in the English county of Hertfordshire. Information available on these individuals includes birthweight (recorded by the attending midwife),…
The Cambridge City over-75s Cohort Study (CC75C) is a long-term follow-up study of a representative population-based sample of older people which started in 1985 from a survey of over 2,600 men and women aged 75 and above. Through a series…
“Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score” has been published in the journal PLOS Medicine. This work was supported in part by JPND through the APGeM project, selected in the 2012 risk…
Biologists have known for decades that enduring a short period of mild stress makes simple organisms and human cells better able to survive additional stress later in life. Now, scientists have found that a cellular process called autophagy is critically…
“Validation of α-Synuclein as a CSF Biomarker for Sporadic Creutzfeldt-Jakob Disease” has been published in the journal Molecular Neurobiology. This work was supported in part by JPND through the DEMTEST project, selected in the 2011 biomarkers call.
An international team of scientists has developed a novel genetic score that allows individuals to calculate their age-specific risk of developing Alzheimer’s disease (AD) based upon genetic information. A description of the polygenic hazard scoring (PHS) system and its validation…
