Category JPND Publications

“Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies” has been published in the Journal of Stem Cell Reports. This work was supported in part by JPND through the MADGIC project

“Age-related ultrastructural changes of the basement membrane in the mouse blood-brain barrier” has been published in the Journal of Cellular and Molecular Medicine. This work was supported in part by JPND through the Prop-AD project

“How much of the missing heritability of ALS is hidden in known ALS genes?” has been published in the Journal of Neurology, Neurosurgery & Psychiatry. This work was supported in part by JPND through the STRENGTH and RiMod-FTD projects.

“Prescribing and deprescribing antihypertensive medication in older people by Dutch general practitioners: a qualitative study” has been published in BMJ Open. This work was supported in part by JPND through the MIND-AD project, selected in the 2013 preventive strategies call

Online Preconcentration in Capillaries by Multiple Large-Volume Sample Stacking: An Alternative to Immunoassays for Quantification of Amyloid Beta Peptides Biomarkers in Cerebrospinal Fluid” has been published in Analytical Chemistry. This work was supported in part by JPND through the PreFrontAls…

“Directing neuronal cell fate in vitro: Achievements and challenges” has been published in Progress in Neurobiology. This work was supported in part by JPND through the EPI-AD project, selected in the 2015 JPco-fuND call.

“Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-β plaques: A potential role in shaping plaque pathology?” has been published in Alzheimer’s & Dementia. This work was supported in part by JPND through the CrossSeeds project, selected in…

“Diabetes Mellitus as a Risk Factor for Parkinson’s Disease: a Molecular Point of View” has been published in Molecular Neurobiology. This work was supported in part by JPND through the aSynProtec project, selected under the 2015 JPco-fuND call.

“Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model” has been published in The Lancet Neurology. This work was supported in part by JPND thorugh the SOPHIA, NETCALS, and STRENGTH projects.

“Presynaptic Regulation of Tonic Inhibition by Neuromodulatory Transmitters in the Basal Amygdala” has been published in Molecular Neurobiology. This work was supported in part by JPND through the CircProt project, selected in the 2015 JPco-fuND call.

“ACO2 homozygous missense mutation associated with complicated hereditary spastic paraplegia” has been published in Neurology Genetics. This work was supported in part by JPND through 3DPD, selected in the 2015 JPco-fuND call.

“Patient experiences of receiving a diagnosis of Parkinson’s disease” has been published in the Journal of Neurology. This work was supported in part by JPND through the CLaSP project, selected in the 2012 healthcare evaluation call.

“The effect of APOE and other common genetic variants on the onset of Alzheimer’s disease and dementia: a community-based cohort study” has been accepted for publication in The Lancet Neurology. This work was supported in part by JPND through the…

“Functional morphology of the blood–brain barrier in health and disease” has been published in Acta Neuropathologica. This work was supported in part by JPND through the SNOWBALL project, selected in the 2015 JPco-fuND call.

“Survival in patients with spinocerebellar ataxia types 1, 2, 3, and 6 (EUROSCA): a longitudinal cohort study” has been published in The Lancet Neurology. This work supported in part by JPND through the ESMI project, selected in the 2015 JPco-fuND…

“Prion-like seeding and nucleation of intracellular amyloid-β” has been accepted for publication in Neurobiology of Disease. This work was supported in part by JPND through the DEMTEST project, selected in the 2011 biomarkers call.

“Molecular subtypes of Alzheimer’s disease” has been published in Scientific Reports. This work was supported in part by JPND through the REfrAME project, selected in the 2015 JPco-fuND call.

“Evaluation of the implementation of the Meeting Centres Support Program in Italy, Poland, and the UK; exploration of the effects on people with dementia” has been published in the International Journal of Geriatric Psychiatry. This work was supported by JPND…

“Stage at which riluzole treatment prolongs survival in patients with amyotrophic lateral sclerosis: a retrospective analysis of data from a dose-ranging study” has been published in The Lancet Neurology. This work was supported in part by JPND through the ALS-CarE…

“Investigation of Neurodegenerative Processes in Amyotrophic Lateral Sclerosis Using White Matter Fiber Density” has been published in Clinical Neuroradiology. This work was supported in part by JPND through the SOPHIA project, selected in the 2011 biomarkers call.

“Pregnancy outcomes in women with spinal muscular atrophy: A review” has been accepted for publication in the Journal of the Neurological Sciences. This work was supported in part by JPND through the DAMNDPATHS project, selected in the 2013 Cross-Disease Analysis…

“Alpha-Synuclein Glycation and the Action of Anti-Diabetic Agents in Parkinson’s Disease” has been published in the Journal of Parkinson’s Disease. This work was supported in part by JPND through the aSynProtec project, selected in the 2015 JPco-fuND call.

“Increasing the efficiency of clinical trials in neurodegenerative disorders using group sequential trial designs” has been accepted for publication in the Journal of Clinical Epidemiology. This work was supported in part by JPND through the SOPHIA project, selected in the…

  “Caldendrin Directly Couples Postsynaptic Calcium Signals to Actin Remodeling in Dendritic Spines” has been accepted for publication in Neuron. This work was supported in part by JPND through the STAD project, selected in the 2015 JPco-fuND call.

“In vivo imaging of early signs of dopaminergic neuronal death in an animal model of Parkinson’s disease” has been accepted for publication in Neurobiology of Disease. This work was supported in part by JPND through the  GBA-PARK project, selected in the 2015 JPco–fuND call.

“Does the community-based combined Meeting Center Support Programme (MCSP) make the pathway to day-care activities easier for people living with dementia? A comparison before and after implementation of MCSP in three European countries” has been published in International Psychogeriatrics. This…

“Animal TSEs and public health: What remains of past lessons?” has been published in PLOS Pathogens. This work was supported in part by JPND through the DEMTEST project, selected in the 2011 biomarkers call.

“Elongator subunit 3 (ELP3) modifies ALS through tRNA modification” has been accepted for publication in Human Molecular Genetics. This work was supported in part by JPND through the RiMod-FTD, STRENGTH, and ALS-CarE projects.

“Fibrotic scarring following lesions to the central nervous system” has been accepted for publication in Matrix Biology. This work was supported in part by JPND through the DACAPO-AD project, selected in the 2015 JPco-fuND call.

“Is Parkinson’s disease a neurodevelopmental disorder and will brain organoids help us to understand it?” has been accepted for publication in Stem Cells and Development. This work was supported in part by JPND through the 3DPD project, selected in the…

“Long-lasting pathological consequences of overexpression-induced α-synuclein spreading in the rat brain” has been published in Aging Cell. This work was supported in part by JPND through the GBA-PARK project, selected in the 2015 JPco-fuND call.

“Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation” has been published in Nature Communications. This work was supported in part by JPND through the TransNeuro and localMND projects, selected in the 2017 Pathways call.

“Engaging older people in an internet platform for cardiovascular risk self-management: a qualitative study among Dutch HATICE participants” has been published in BMJ Open. This work was supported in part by JPND through the MIND-AD project, selected in the 2013…

“In Vivo Transient and Partial Cell Reprogramming to Pluripotency as a Therapeutic Tool for Neurodegenerative Diseases” has been published in Molecular Neurobiology. This work was supported in part by JPND through the DAMNDPATHS project, selected in the 2013 cross-disease analysis call.

“Neuroinflammatory responses in Alzheimer’s disease” has been published in the Journal of Neural Transmission. This work was supported in part by JPND through the MADGIC project, selected under the 2015 JPco-fuND call.

“Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy” has been published in Stem Cell Reports. This work was supported in part by JPND through the CureALS project, selected in…

“Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease” has been published in Nature. This work was supported in part by JPND through the InCure project, selected in the 2013 call for European research projects for Cross-Disease Analysis of Pathways related…

“Hot-spot KIF5A mutations cause familial ALS” has been published in Brain. This work was supported in part by JPND through the STRENGTH project, selected in the 2012 risk factors call, and the PreFrontAls project, selected in the 2013 preventive strategies…

“Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis” has been published in Acta Neuropathologica. This work was supported in part by JPND through the NEEDS in ALS project, selected in the 2012 healthcare evaluation…

“Time Is Motor Neuron: Therapeutic Window and Its Correlation with Pathogenetic Mechanisms in Spinal Muscular Atrophy” has been published in Molecular Neurobiology. This work was supported in part by JPND through the DAMNDPATHS project, selected under the 2013 call for…

  “A novel cognitive-functional composite measure to detect changes in early Alzheimer’s disease: Test–retest reliability and feasibility” has been published in Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring. This work was supported in part by JPND through the EURO-SCD…

    “Existential decision-making in a fatal progressive disease: how much do legal and medical frameworks matter?” has been published in BMC Palliative Care. This work was supported by JPND through the NEEDS in ALS project, selected in the 2012…

“Differential overexpression of SERPINA3 in human prion diseases” has been published in the journal Scientific Reports. The work was supported in part by the REfrAME project, selected in the 2015 JPco-fuND call.

“Targeted genetic screen in Amyotrophic Lateral Sclerosis reveals novel genetic variants with syngergistic effect on clinical phenotype” has been published in the journal Frontiers in Molecular Neuroscience. This work was supported in part by the SOPHIA project, selected in the…

“Age-related epigenetic changes in hippocampal subregions of four animal models of Alzheimer’s disease” has been published in the journal Molecular and Cellular Neuroscience. This work was supported in part by the EPI-AD project, which was selected in the 2015 JPco-fuND…

“Gut microbiota changes in the extreme decades of human life: a focus on centenarians” has been published in the journal Cellular and Molecular Life Sciences. This work was supported in part by JPND through the ADAGE project, selected in the…

“Multimodal correlation of dynamic [18F]-AV-1451 perfusion PET and neuronal hypometabolism in [18F]-FDG PET” has been published in the European Journal of Nuclear Medicine and Molecular Imaging. This project was supported in part by JPND through the BIOMARKAPD project, selected in…

“No Escaping the Rat Race: Simulated Night Shift Work Alters the Time-of-Day Variation in BMAL1 Translational Activity in the Prefrontal Cortex” has been published in the journal Frontiers in Neural Circuits. This work was supported in part by JPND through…

“Plasma level of club-cell (CC-16) predicts outcome in amyotrophic lateral sclerosis” has been published in the journal Acta Neurologica Scandinavica. This work was supported in part by JPND through the ONWebDUALS project, selected in the 2013 Preventative Strategies call.

“Long-Term Air Pollution Exposure and Amyotrophic Lateral Sclerosis in Netherlands: A Population-based Case–control Study” has been published in the journal Environmental Health Perspectives. This work was supported in part by JPND through the SOPHIA project, selected in the 2011 Biomarkers…