Category JPND Publications

The JPND working group on vascular contributions to neurodegeneration, which was selected under the 2014 call for working groups on cohort studies, brought together 55 international experts on brain disease and dementia to survey the data from more than 90…

“A comparative study of peripheral nerve MRI and ultrasound in MMN and ALS” has been published in Muscle & Nerve. This research was supported in part by JPND through the STRENGTH project, selected for support in the 2012 risk factors…

“Revisiting rodent models: Octodon degus as Alzheimer’s disease model?” has been published in Acta Neuropathologica Communications. This research was supported in part by JPND through the NeuroGem project, selected under the 2013 cross-disease analysis call, and the PROP-AD project, selected…

“Cerebrospinal α-synuclein in α-synuclein aggregation disorders: tau/α-synuclein ratio as potential biomarker for dementia with Lewy bodies” has been published in the Journal of Neurology. This research was supported in part by JPND through the DEMTEST project, selected in the 2011…

“A Surveillance Function of the HSPB8-BAG3-HSP70 Chaperone Complex Ensures Stress Granule Integrity and Dynamism” has been published in Molecular Cell. This research was supported in part by JPND through the CureALS project, selected under the 2015 JPco-fuND call.

“Measurement of Social Cognition in Amyotrophic Lateral Sclerosis: A Population Based Study” has been published in PLOS ONE. This research was supported in part by JPND through the SOPHIA project, selected under the 2011 biomarkers call.

“Access to timely formal dementia care in Europe: protocol of the Actifcare (ACcess to Timely Formal Care) study” has been published in BMC Health Services Research. This research was supported by JPND through the Actifcare project, selected under the 2012…

“Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia” has been published in Acta Neuropathologica Communications. This research was supported in part by JPND through the DACAPO-AD project, selected under the 2015…

“The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6” has been published in Nature. This work was supported in part by JPND through the CureALS project and the REfrAME project, both selected under the 2015 JPco-fuND…

“Supportive and symptomatic management of amyotrophic lateral sclerosis“ has been published in Nature Reviews Neurology. This work was supported in part by JPND through the ALS-CarE project, selected under the 2012 healthcare call.

“The choroid plexus in health and in disease: Dialogues into and out of the brain” has been published in Neurobiology of Disease. This research was supported in part by JPND through the NeuroGem project, selected under the 2013 cross-disease analysis…

“The β-amyloid peptide compromises Reelin signaling in Alzheimer’s disease” has been published in Scientific Reports. This research was supported in part by JPND through the BiomarkAPD project, selected under the 2011 biomarkers call.

“Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer’s Disease” has been published in Molecular Neurobiology. This research was supported in part by the CrossSeeds project, selected for support in the 2013 cross-disease call.

“Low Cerebrospinal Fluid Amyloid-Beta Concentration Is Associated with Poorer Delayed Memory Recall in Women” has been published in Dementia and Geriatric Cognitive Disorders Extra. This research was supported in part through the BIOMARKAPD project, selected in the 2011 biomarkers call.

“Fibroblasts of Machado Joseph Disease patients reveal autophagy impairment” has been published in Scientific Reports. This research was supported in part by JPND through the  ModelPolyQ project, selected for support under the 2015 JPco-fuND call, and the SynSpread project, selected…

“Laser capture microscopy coupled with Smart-seq2 for precise spatial transcriptomic profiling” has been published in Nature Communications. This research was supported in part by JPND through the DAMNDPATHS project, selected under the 2013 cross-disease analysis call.

“Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study” has been published in Brain. This research was supported in part by JPND through the BiomarkAPD project, selected under the 2011 biomarkers call.

“Application of an in vitro-amplification assay as a novel pre-screening test for compounds inhibiting the aggregation of prion protein scrapie” has been published in Scientific Reports. This research was supported in part by JPND through the DEMTEST project, selected under…

“Inside out: the role of nucleocytoplasmic transport in ALS and FTLD” has been published in Acta Neuropathologica. This research was supported in part by JPND through the STRENGTH and RiMod-FTD projects, selected under the 2012 risk factors call.

“Comprehensive promoter level expression quantitative trait loci analysis of the human frontal lobe” has been published in Genome Medicine. This research was supported in part by JPND through the RiMod-FTD project, selected under the 2012 risk factors call.

“Creation of a library of induced pluripotent stem cells from Parkinsonian patients” has been published in npj Parkinson’s Disease. This research was supported in part by JPND through the MADGIC project, selected under the 2015 JPco-fuND call.

“Aiming for Study Comparability in Parkinson’s Disease: Proposal for a Modular Set of Biomarker Assessments to be Used in Longitudinal Studies” has been published in Frontiers in Aging Neuroscience. This research was supported by JPND through the BioLoC-PD working group, selected…

“Presenilin 2 Modulates Endoplasmic Reticulum-Mitochondria Coupling by Tuning the Antagonistic Effect of Mitofusin 2” has been published in Cell Reports. This research was supported in part by JPND through the CeBioND project, which was selected in the 2013 call for…

“Discordant performance on the ‘Reading the Mind in the Eyes’ Test, based on disease onset in amyotrophic lateral sclerosis” has been published in Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. This research was supported in part by JPND through the SOPHIA…

“Tryptophan hydroxylase type 2 variants modulate severity and outcome of addictive behaviors in Parkinson’s disease” has been published in Parkinsonism & Related Disorders. This research was supported in part by JPND theough the COURAGE-PD project, selected in the 2012 risk…

“CSF Aβ1–42 – an excellent but complicated Alzheimer’s biomarker – a route to standardisation” has been published in Clinica Chimica Acta. This research was supported in part by JPND through the BIOMARKAPD project, selected in the 2011 biomarkers call.

“Neurochemical biomarkers in the diagnosis of frontotemporal lobar degeneration: An update” has been published in the Journal of Neurochemistry. This research was supported in part by JPND through the SOPHIA and BiomarkAPD projects, selected in the 2011 biomarkers call, and…

“Understanding Dopaminergic Cell Death Pathways in Parkinson Disease” has been published in Neuron. This research was supported in part by JPND through the CrossSeeds project, selected in the 2013 call for research projects for cross-disease analysis of pathways related to…

“The segmental diffusivity profile of amyotrophic lateral sclerosis associated white matter degeneration“ has been published in the European Journal of Neurology. This research was supported in part by JPND through the SOPHIA project, which was selected in the 2011 biomarkers…

“Conversion of Synthetic Aβ to In Vivo Active Seeds and Amyloid Plaque Formation in a Hippocampal Slice Culture Model” has been published in The Journal of Neuroscience. This research was supported in part by JPND through the NeuTARGETs project, which…

“Differential neuronal vulnerability identifies IGF-2 as a protective factor in ALS” has been published in Scientific Reports. This research was supported in part by JPND.

“Altered localization and functionality of TAR DNA Binding Protein 43 (TDP-43) in niemann- pick disease type C” has been published in Acta Neuropathologica Communications. This research was supported in part by sponsor Buzzoid and JPND through the RiMod-FTD project, selected in…

“Analysis of terms used for the diagnosis and classification of amyotrophic lateral sclerosis and motor neuron disease” has been published in Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. This research was supported in part by JPND through the STRENGTH project, selected…

“Criteria for folding in structure-based models of proteins” has been published in The Journal of Chemical Physics. This research was supported in part by JPND through the MisingLink project, selected in the 2013 cross-disease analysis call.

“Does the MUNIX Method Reflect Clinical Dysfunction in Amyotrophic Lateral Sclerosis: A Practical Experience” has been published in Medicine. This research was supported in part by JPND through the OnWebDUALS project, selected in the 2013 preventive strategies call, and the…

“Protein biomarkers in Parkinson’s disease: Focus on cerebrospinal fluid markers and synaptic proteins” has been published in Movement Disorders. This research was supported in part by JPND through the BiomarkAPD and SOPHIA projects, selected in the 2011 biomarkers call, and…

“Quality Control of Motor Unit Number Index (MUNIX) Measurements in 6 Muscles in a Single-Subject ‘Round-Robin’ Setup” has been published in PLOS ONE. This research was supported in part by JPND through the SOPHIA project, selected in the 2011 biomarkers call.

“Cerebrospinal fluid soluble TREM2 in aging and Alzheimer’s disease” has been published in Alzheimer’s Research & Therapy. This research was supported in part by JPND through the APGeM project, selected in the 2012 risk factors call.

A paper titled “Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy” has been published in The American Journal of Human Genetics. This research was supported in part by JPND through the COURAGE-PD project, selected…

A paper titled “Soluble amyloid induces hypersynchrony of BOLD resting-state networks in transgenic mice and provides an early therapeutic window before amyloid plaque deposition” has been published in Alzheimer’s & Dementia. This research was supported by JPND through the CrossSeeds…

A paper titled “Awaji Criteria Improves the Diagnostic Sensitivity in Amyotrophic Lateral Sclerosis: a Systematic Review Using Individual Patient Data” has been published in Clinical Neurophysiology. This research was supported by JPND through the STRENGTH project, which was selected in…

A paper titled “Case report of concurrent Fabry disease and amyotrophic lateral sclerosis supports a common pathway of pathogenesis” has been published in Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. This research was supported by JPND through the SOPHIA, STRENGTH and…

A paper titled “The selective anatomical vulnerability of ALS: ‘disease-defining’ and ‘disease-defying’ brain regions” has been published in Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. The research group of Orla Hardiman received support from JPND through the SOPHIA project, which was…

A new paper titled “C9orf72 is differentially expressed in the central nervous system and myeloid cells and consistently reduced in C9orf72, MAPT and GRN mutation carriers” has been published in Acta Neuropathologica Communications. It was partly funded by JPND through…

A new paper titled “Identification of new molecular alterations in Fatal Familial Insomnia” has been published in Human Molecular Genetics. It was in part funded by JPND through the DEMTEST project, which was selected for support in the 2011 biomarkers…

A new paper titled “Structural and functional properties of prefibrillar α-synuclein oligomers” has been published in Scientific Reports. It was partly funded by JPND through the NeuTARGETs project, which was selected for support in the 2013 call for research projects…