Category JPND Publications

“Parkinson’s Disease-Associated Mutant LRRK2-Mediated Inhibition of miRNA Activity is Antagonized by TRIM32” has been published in the journal Molecular Neurobiology. This work was supported in part by JPND through the 3DPD project, selected in the 2015 JPco-fuND call and the SynSpread project,…

“Pre-Clinical Evaluation Of A Lentiviral Vector For Huntingtin Silencing” has been published in the journal Molecular Therapy: Methods & Clinical Development. This work was supported in part by JPND through the ModelPolyQ project, selected in the 2015 JPco-fuND call.

“Deletion of exons 9 and 10 of the Presenilin 1 gene in a patient with Early-onset Alzheimer Disease generates longer amyloid seeds” has been published in the journal Neurobiology of Disease. This work was supported in part by JPND through…

“Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo” has been published in the journal Human Molecular Genetics. This work was supported in part by JPND through the STRENGTH and RiMod-FTD projects, selected in the 2012…

“Modelling amyotrophic lateral sclerosis: progress and possibilities” has been published in the journal Disease Models & Mechanisms. This work was supported in part by JPND through the STRENGTH and RiMod-FTD projects, selected in the 2012 Risk Factors call.

“Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria” has been published in the journal Movement Disorders. This work was supported in part by JPND through the ASAP SynTau project, selected in the 2016 Brain Imaging Working Groups…

“The biological function of the cellular prion protein: an update” has been published in the journal BMC Biology. This work was supported in part by JPND through the CureALS and REfrAME projects, selected in the 2015 JPco-fuND call.

“Validation of qPCR reference genes in lymphocytes from patients with amyotrophic lateral sclerosis” has been published in the journal PLOS Medicine. This work was supported in part by JPND through the SOPHIA project, selected in the 2011 Biomarkers call.

“Therapeutic Strategies Under Development Targeting Inflammatory Mechanisms in Amyotrophic Lateral Sclerosis” has been published in Molecular Neurobiology. This work was supported in part by JPND through the DAMNDPATHS project, selected in the 2013 Cross-Disease Analysis call.

“Discovery and systematic functional validation of Parkinson’s disease genes from exome sequencing (S1.003)” has been published in Neurology. This work was supported in part by JPND through the 3DMiniBrain project, selected in the 2015 JPco-fuND call.

“FEWDON-MND syndrome (finger extension weakness and downbeat nystagmus): A novel motor neuron disorder?” has been published in the journal Muscle & Nerve. This work was supported in part by JPND through the STRENGTH project, selected in the 2012 Risk Factors…

“The role of high-field magnetic resonance imaging in parkinsonian disorders: Pushing the boundaries forward” has been published in the journal Movement Disorders. This work was supported in part by JPND through the APGeM project, selected in the 2012 Risk Factors call.

“A cross-sectional population-based investigation into behavioral change in amyotrophic lateral sclerosis: subphenotypes, staging, cognitive predictors, and survival” has been published in the journal Annals of Clinical and Translational Neurology. This work has been supported in part by JPND through the ALS-CarE…

“Posttranslational modification impact on the mechanism by which amyloid‐β induces synaptic dysfunction” has been published in EMBO Reports. This work was supported in part by JPND through the STAD project, selected in the 2015 JPco-fuND call.

“The need for harmonization and innovation of neuropsychological assessment in neurodegenerative dementias in Europe: consensus document of the Joint Program for Neurodegenerative Diseases Working Group” has been published in the journal Alzheimer’s Research & Therapy. This work was supported in…

“Survival prediction in Amyotrophic Lateral Sclerosis on MRI measures and clinical characteristics” has been published in the journal BMC Neurology. This work was supported in part by JPND through the SOPHIA project, selected in the 2011 Biomarkers call.

“Poly-GP in cerebrospinal fluid links C9orf72-associated dipeptide repeat expression to the asymptomatic phase of ALS/FTD” has been published in the journal EMBO Molecular Medicine. This work was supported in part by JPND through the SOPHIA project, selected in the 2011 Biomarkers call,…

“Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells” has been published in the journal Stem Cell Reports. This work was supported in part by JPND through the 3DPD project, selected in the 2015 JPco-fuND call.

“Motor neuron vulnerability and resistance in amyotrophic lateral sclerosis” has been published in the journal Acta Neuropathologica. This work has been supported in part by JPND through the DAMNDPATHS project, selected in the 2013 Cross-Disease Analysis call.

“Integrated molecular landscape of Parkinson’s disease” has been published in the journal NPJ Parkinson’s Disease. This work has been supported in part by JPND through the COURAGE-PD project, selected in the 2012 risk factors call.

“APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases” has been published in the journal PLOS Medicine. This work was supported in part by JPND through the PERADES project, selected in…

“Brachial plexus magnetic resonance imaging differentiates between inflammatory neuropathies and does not predict disease course” has been published in the journal Brain and Behavior. This work was supported in part by JPND through the SOPHIA project, selected in the 2011 biomarkers…

“An aberrant phase transition of stress granule triggered by misfolded protein and prevented by chaperione function” has been published in The EMBO Journal. This work has been supported in part by JPND through the CureALS project, selected in the 2015…

“Comparison of the adaptive implementation and evaluation of the Meeting Centers Support Program for people with dementia and their family careers in Europe; study protocol of the MEETINGDEM project” has been published in the journal BMC Geriatrics. This work has…

“Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis” has been published in the journal Science Translational Medicine. This work was supported in part by JPND through the STRENGTH project, selected in the 2012 risk factors call.

“Serum miRNAs miR-206, 143-3p and 374b-5p as potential biomarkers for amyotrophic lateral sclerosis (ALS)” has been published in the journal Neurobiology of Aging. This work has been supported in part by JPND through the STRENGTH project, selected in the 2012…

“The effects of an extensive programme on the progression of Mild Cognitive Impairment (MCI): study protocol for a randomized controlled trial” has been published in the journal BMC Geriatrics. This work was supported by JPND through the NeuroExercise project, selected…

“Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score” has been published in the journal PLOS Medicine. This work was supported in part by JPND through the APGeM project, selected in the 2012 risk…

“Validation of α-Synuclein as a CSF Biomarker for Sporadic Creutzfeldt-Jakob Disease” has been published in the journal Molecular Neurobiology. This work was supported in part by JPND through the DEMTEST project, selected in the 2011 biomarkers call.

“The Alzheimer’s disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway” has been published in the Journal of Neuroinflammation. This work was supported in part by JPND through the APGeM project, selected in the 2012…

“Clinical validity of medial temporal atrophy as a biomarker for Alzheimer’s disease in the context of a structured 5-phase development framework” has been published in the journal Neurobiology of Aging. This work was supported in part by JPND through the BIOMARKAPD…

“Phase separation of C9orf72 Dipeptide Repeats Pertubs Stress Granule Dynamics” has been published in the journal Molecular Cell. This work was supported in part by JPND through the RiMod-FTD project, selected in the 2012 risk factors call.

“Exploring the fitness hypothesis in ALS: a population-based case-control study of parental cause of death and lifespan” has been published in the Journal of Neurology, Neurosurgery & Psychiatry. This work was supported in part by JPND through the SOPHIA project,…

“APP Function and Lipids: A Bidirectional Link” has been published in Frontiers in Molecular Neuroscience. This work was supported in part by JPND through the MIND-AD project, selected for support in the 2013 preventive strategies call.

“Measurement of Rapid Protein Diffusion in the Cytoplasm by Photo-Converted Intensity Profile Expansion” has been published in Cell Reports. This work was supported in part by JPND through the CureALS project, selected in the 2015 JPco-fuND call.

“Amplifying mitochondrial function rescues adult neurogenesis in a mouse model of Alzheimer’s disease” has been published in Neurobiology of Disease. This work was supported in part by JPND through the MADGIC project, selected in the 2015 JPco-fuND call.

“Mutations in TMEM230 are rare in autosomal dominant Parkinson’s disease” has been published in Parkinsonism & Related Disorders. This work was supported in part by JPND through the DAMNDPATHS project, selected in the 2013 cross-disease analysis call.

“Transfer of disrupted-in-schizophrenia 1 aggregates between neuronal-like cells occurs in tunnelling nanotubes and is promoted by dopamine” has been published in Open Biology. This work was supported in part by JPND through the NeuTargets project, selected in the 2013 cross-disease…

“Arterial spin labelling detects posterior cortical hypoperfusion in non-demented patients with Parkinson’s disease” has been published in the Journal of Neural Transmission. This work was supported in part by JPND through the APGeM project, selected in the 2012 risk factors…

“The Synucleinopathies: Twenty Years On” has been published in the Journal of Parkinson’s Disease. This work was supported in part by JPND through the REfrAME project, selected in the 2015 JPco-fuND call.

“Striato-cortical connections in Parkinson’s and Alzheimer’s diseases: Relation to cognition” has been published in Movement Disorders. This work was supported in part by JPND through the APGeM project, selected in the 2012 risk factors call.

“Role of neuroinflammation in neurodegeneration: new insights” has been published in Alzheimer’s Research & Therapy. This work was supported in part by JPND through the InCure project, selected in the 2013 cross-disease analysis call.

“Reporting on methods to generate and purify rodent and human oligodendrocytes from different sources” has been published in Stem Cell Research. This work was supported in part by JPND through the MADGIC project, selected in the 2015 JPco-fuND call.

“Does Global Astrocytic Calcium Signaling Participate in Awake Brain State Transitions and Neuronal Circuit Function?” has been published in Neurochemical Research. This work was supported in part by JPND through the DACAPO-AD project, selected in the 2015 JPco-fuND call.

“Cross-talk between LRRK2 and PKA: implication for Parkinson’s disease?” has been published in Biochemical Society Transactions. This work was supported in part by JPND through the InCure project, selected in the 2013 cross-disease analysis call.

“Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein” has been published in PLOS ONE. This work was supported in part by JPND through the CureALS project, selected in the 2015…

“Profile of 6 microRNA in blood plasma distinguish early stage Alzheimer’s disease patients from non-demented subjects” has been published in Oncotarget. This work was supported in part by JPND through the BIOMARKAPD project, selected in the 2011 biomarkers call.

“A composite measure of cognitive and functional progression in Alzheimer’s disease: Design of the Capturing Changes in Cognition study” has been published in Alzheimer’s & Dementia: Translational Research & Clinical Interventions. This work was supported in part by JPND through…

“Unravelling endogenous MicroRNAs system dysfunction as a new pathophysiological mechanism in Machado-Joseph disease” has been accepted for publication in Molecular Therapy. This work was supported in part by JPND through the SynSpread, ESMI and ModelPolyQ projects.

“No association between gluten sensitivity and amyotrophic lateral sclerosis” has been published in the Journal of Neurology. This work was supported in part by JPND through the SOPHIA, STRENGTH, and ALS-CarE projects.