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Cohort Acronym

Cohort type
Neurodegenerative disease-specific cohort

Alzheimer's disease, Frontotemporal dementia, Mild cognitive impairment (MCI), Subjective memory complaints (SMC) or subjective cognitive decline (SCD), Vascular dementia

Participant type
At-risk diagnosis

Recruitment Period May 11-Dec 12 
Sample size at start or planned sample size if still recruiting 300  
Estimated Current Sample Size 0 to 4,999 
Age at Recruitment 40-80   
Gender Male and Female 

The Gipuzkoa Alzheimer Project (PGA) is a longitudinal study on pre-clinical Alzheimer’s disease. This study aims to investigate the prevalence, clinical, cognitive and neuroimaging features and potential risk factors related to cardiovascular health and lifestyles for pre-clinical AD in asymptomatic (or very mildly symtopmatic, e.g. SCD) subjects from the community.

Follow-up Scheduled every 3 years for a minimum of 12 years. The first 3-year follow-up was completed in June 2015. The loss of subjects in the follow up was 9 %. 80% of people who donated cerebrospinal fluid at the baseline visit did the same in this follow-up visit. Second follow-up visit (6 yrs) to be started in April 2017.

Last update: 16/01/2017

Country Spain 
Contact details
Institution name Fundación CITA-Alzheimer Fundazioa 
Principal Investiator (PI) Dr. Pablo Martinez-Lage 
Contact email PI Email: [email protected] 
Contact phone number +34 (0) 943021792 
Address Fundación CITA-Alzheimer Fundazioa
Pº Mikeletegi 71
20009 Donostia-San Sebastián
Funders (Core support) Fundacion Cita-Alzheimer Fundazioa
Basque Government
Gipuzkoa Local Government
Kutxa Fundazioa 

Variables Collected

Brain related measures: Mental health
Funtional rating: Individual physiological, Individual psychological
Anthropometric: Blood pressure, Height, Hip circumference, Waist circumference, Weight
Physical: Cardiovascular
Biological samples: Blood, Urine
Genotyping: N/A
Brain imaging: Magnetic resonance imaging (MRI), Magnetic resonance spectroscopy (MRS)
Brain banking: N/A
Lifestyle: Alcohol, Dietary habits, Physical activity, Smoking
Socio-economic: N/A
Health service utilisation: N/A
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