Principal Investigators

    Dr. Nienke Timmer


    Radboud university medical center, dept. anatomy, Nijmegen

    Contact information of lead PI



    Title of project or programme

    Identification of novel a?-associated proteins

    Source of funding information

    alzheimer nederland (ISAO)

    Total sum awarded (Euro)

    € 50,000

    Start date of award


    Total duration of award in years



    Research Abstract

    The amyloid β (Aβ) protein is crucial in the pathogenesis of Alzheimer’s disease (AD), but its fate is affected by interaction with A?-associated proteins such as ApoE and heparan sulphate proteoglycans. Usually, end-stage AD brain tissue is used to identify Aβ-associated proteins. We postulate that hitherto unknown Aβ-binding proteins, that play a role in the earliest stages of plaque development, may shed new light on the way Aβ is deposited. With a recently established method using soluble Aβ as bait, we aim to identify these novel early Aβ-binding proteins.

    Further information available at:

Types: Investments < €500k
Member States: Netherlands
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

Export as PDF