Principal Investigators


Dr. Nienke Timmer

Institution


Radboud university medical center, dept. anatomy, Nijmegen

Contact information of lead PI


Country


Netherlands

Title of project or programme


Identification of novel a?-associated proteins

Source of funding information


alzheimer nederland (ISAO)

Total sum awarded (Euro)


€ 50,000

Start date of award


15/03/2015

Total duration of award in years


2

Keywords


Research Abstract


The amyloid β (Aβ) protein is crucial in the pathogenesis of Alzheimer’s disease (AD), but its fate is affected by interaction with A?-associated proteins such as ApoE and heparan sulphate proteoglycans. Usually, end-stage AD brain tissue is used to identify Aβ-associated proteins. We postulate that hitherto unknown Aβ-binding proteins, that play a role in the earliest stages of plaque development, may shed new light on the way Aβ is deposited. With a recently established method using soluble Aβ as bait, we aim to identify these novel early Aβ-binding proteins.

Further information available at:


https://www.alzheimer.nl/onderzoek/onderzoeksprojecten/project/identificatie-van-nieuwe-amyloid-s-geassocieerde-eiwitten

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