Name of Fellow

    Piotr Hanczyc



    Contact information of fellow



    Title of project/programme

    Novel applications of multiphoton absorption for the detection of Alzheimer´s disease-linked amyloid aggregates and biomaterials for blood amyloid fibril capture systems.

    Source of funding information

    Total sum awarded (Euro)

    € 342,764

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    amyloid fibrils | multiphoton absorption | brain diseases | Biomaterials | Alzheimer

    Research Abstract

    Based on results obtained during my PhD in relation to the use of multiphoton absorption for analyzing dye-linked DNA and proteins I propose to expand this technology to the analysis of protein aggregates, e.g., amyloid fibrils in medical and biomaterial contexts. Nonlinear optics has the possibility to detect and diagnose amyloid fibril formation in the brains of persons with suspected Alzheimer´s or Parkinson´s disease, with potentially enormous benefits to patients and society. Importantly, high-intensity light in the infrared region of absorption does not damage cells and tissues during long-duration irradiation, it does not require the use of chemical labels, and reduces the need for surgical intervention. Amyloid fibrils are also becoming an attractive biomaterial based on their ability to assemble synthetic molecules upon fibrilization. Tissue-biocompatible non-toxic polymers with affinity to amyloids represent a class of nano-designed compounds that can successfully replace standard drugs and pharmaceutics used as disease inhibitors.

Types: Fellowships
Member States: Sweden
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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