«Age-related ultrastructural changes of the basement membrane in the mouse blood-brain barrier» has been published in the Journal of Cellular and Molecular Medicine. This work was supported in part by JPND through the Prop-AD project
Monthly Archives: noviembre 2018
Launched on 1 November 2018, the European Brain Council (EBC)-coordinated EU project The European Brain Research Area (EBRA), was designed to respond to the Horizon 2020 call SC1-HCO-10-2018, entitled ‘Coordinating European brain research and developing global initiatives’.
Aimed at reducing the fragmentation and duplication of research efforts and at fostering synergies through enhanced coordination of brain research efforts at the EU and global level, the EBRA project was created as a catalysing platform for brain research stakeholders (researchers, clinicians, patients, governments, funders and public institutions) to streamline and better co-ordinate brain research across Europe while fostering global initiatives.
The highly diversified nature of European public research represents a considerable obstacle in the European Research Area, especially in the field of brain research, where the complexity of brain imposes a coordinated research effort to advance the understanding of brain and its disorders.
The EU and its Member States have made considerable investments in brain research, leading to a significant increase of initiatives in this area, particularly under Horizon 2020. Although these initiatives have generated considerable amounts of knowledge and innovative approaches, more coordinated efforts to identify gaps and highlight priorities are needed, to combat the complexity of the challenge.
Over the next three years, the EBRA Consortium will work to align and better coordinate research strategies across European and global brain initiatives; facilitating the emergence of research projects in specific areas in active clusters, and providing support for effective collaboration. This includes enabling the sharing of data and access to research infrastructures; increasing the visibility of the brain research portfolio as a whole and promoting the uptake of EBRA results to key stakeholders.
The Consortium consists of the EBC membership, the Network of European funding for Neuroscience research (NEURON), Joint Programme – Neurodegenerative Disease Research (JPND) and the Human Brain Project (HBP).
This project has received funding from the European Union’s Horizon 2020 Research and Innovation programme under grant agreement No 825348
The EU Joint Programme – Neurodegenerative Disease Research (JPND) will shortly launch a new cohesive action with the European Commission – a call for “Multinational research projects on Personalised Medicine for Neurodegenerative Diseases”. More than €30 million have already been earmarked by JPND member countries and the European Commission for this action.
Neurodegenerative diseases are debilitating and still largely untreatable conditions. They are characterised by a large variability in their origins, mechanisms and clinical expression. When searching for a medical solution, e.g. a treatment or an optimised approach for care, this large variability constitutes a major hurdle if not controlled. Indeed a treatment addressing one disease pathway may not be useful for all patients experiencing the relevant symptoms. Thus, one of the greatest challenges for treating neurodegenerative diseases is the deciphering of this variability.
JPND has chosen to focus in the area of Precision Medicine, which relates to the targeting of specific elements responsible for pathology in a given individual at a particular point in time. It is an emerging approach for disease prevention, diagnosis and treatment that takes into account individual variability in genes, biological/molecular characteristics together with environmental and lifestyle factors.
Thus, the upcoming call for multidisciplinary research proposals conducted by JPND and the European Commission will focus on Precision Medicine in the following research areas:
- Diagnosis (e.g. biomarkers, imaging data, omics approaches, big data analyses)
- Prevention (e.g. biomarkers for studying novel treatments and interventions, co-morbidities, digital technologies, stratification within cohort studies and clinical trials)
- Care (e.g. improvement of social and health care systems, molecular profiling, imaging, lifestyle data)
The following neurodegenerative diseases are included in the call:
- Alzheimer’s disease and other dementias
- Parkinson’s disease and PD‐related disorders
- Prion diseases
- Motor neuron diseases
- Huntington’s disease
- Spinocerebellar ataxia (SCA)
- Spinal muscular atrophy (SMA)
This will be a two-step call, expected to be launched in early January 2019, with a likely pre-proposal submission deadline in March 2019. Further details will be provided with the launch of the call.
Please note:
All information regarding future JPND call topics is subject to change.
Final call information will be published on the call page.
The EU Joint Programme on Neurodegenerative Disease Research (JPND) has awarded funding to ten multi-national research teams in order to increase understanding of the factors that contribute to the quality and delivery of health and social care for neurodegenerative diseases.
Current research suggests strong potential for improving quality of life for those living with neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease, with novel health and social care concepts and innovations focusing on the preservation of dignity, independence and social inclusion. Nevertheless, the availability and quality of such services vary considerably across Europe and beyond.
JPND has selected ten teams with ambitious, innovative and multi-disciplinary collaborative projects that address health and social care at both the macro level of systems and infrastructures and the individual level of patients, carers and families.
“While waiting for new treatments to emerge from basic and translational research, we need to support projects that could deliver immediate impactful developments which health and social care research and innovation may be able to achieve. This includes new insights that point to the potential for improved patient empowerment, civic participation and quality of life,” said Professor Philippe Amouyel, Chair of JPND. “Our hope is that this work will lead to the adoption of novel health promotion strategies that will reduce the impact of disease for patients as well as for their families and carers.”
The ten projects were recommended for funding by an independent, international Peer Review Panel based on scientific excellence with input from the JPND advisory board on patient and public involvement. Proposals are presented in alphabetical order according to their acronym.
Visit the call page here.
ADDITION
Alzheimer’s disease data-driven insights on individual outcomes of importance
Coordinator:
Linus Jönsson, Karolinska Institutet, Sweden
Partners:
Wiesje van der Flier, VU University Medical Center, The Netherlands
Carole Dufouil, INSERM, University of Bordeaux, France
COGNISANCE
CO-desiGning demeNtia dIagnoSis ANd post-diagnostic CarE
Coordinator:
Henry Brodaty, University of New South Wales, Australia
Partners:
Lee-Fay Low, University of Sydney, Australia
Isabelle Vedell, McGill University, Canada
Frans Verhey F, Maastricht University, The Netherlands
Greta Rait, University College London, United Kingdom
Louise Robinson, Newcastle University Institute for Ageing, United Kingdom
Joanna Rymaszewska, Wroclaw Medical University, Poland
DOMINO-HD
Multi-Domain Lifestyle Targets for Improving ProgNOsis in Huntington’s Disease
Coordinator:
Monica Busse, Centre for Trials Research, Cardiff University, United Kingdom
Partners:
Madeleine Lowery, Insight Centre for Data Analytics, University College Dublin, Ireland
Esther Cubo, Hospital Universitario of Burgos, Spain
Grzegorz Witkowski, Institute of Psychiatry and Neurology, Warsaw, Poland
Bernhard Landwehrmeyer, University of Ulm, Germany
Hans Jung, University of Zurich, Switzerland
FCDS Study
Scaling up the Family Carer Decision Support Intervention: A transnational effectiveness-implementation evaluation
Coordinator:
Kevin Brazil, Queen’s University Belfast, United Kingdom
Partners:
Sharon Kaasalainen, McMaster University, Canada
Jenny van der Steen, Leiden University Medical Centre, The Netherlands
Nicola Cornally, University College Cork, Republic of Ireland
Martin Loucka, Center for Palliative Care, Czech Republic
HEALTHE-RND
European eHealth care model for rare neurodegenerative diseases
Coordinator:
Jiri Klempir, Charles University in Prague, Czech Republic
Partners:
Jennifer Hoblyn, Bloomfield Hospital, Trinity College Dublin, Ireland
Ferdinando Squitieri, Huntington and Rare Diseases Unit, IRCCS Casa Sollievo della Sofferenza Hospital, Italy
Wilco Achterberg, Leiden University Medical Center, Topaz Huntington Center Overduin, The Netherlands
Niels Chavannes, Leiden University Medical Center, Department of Public Health and Primary Care, The Netherlands
Bernhard Landwehrmeyer, University of Ulm, Germany
Stephen P McKenna, Galen Research, Manchester, United Kingdom
HOMESIDE
A HOME-based Spousal caregiver-delivered music Intervention for people living with DEmentia: A Randomised Controlled Trial
Coordinator:
Felicity Baker, The University of Melbourne, Australia
Partners:
Karette Stensæth, Norwegian Academy of Music, Norway
Helen Odell-Miller, Anglia Ruskin University, United Kingdom
Thomas Wosch, University of Applied Sciences Würzburg-Schweinfurt, Germany
Anna Bukowska, University of Physical Education in Krakow, Poland
iCARE-PD
Integrated Parkinson Care Networks: addressing complex care in Parkinson disease in contemporary society
Coordinator:
Tiago Mestre, The Ottawa Hospital Research Institute / University of Ottawa, Canada
Partners:
Carsten Eggers, Philipps University of Marburg, Germany
Álvaro Sanchez-Ferro, Fundación Investigación HM Hospitales, Spain
Olivier Rascol, Toulouse University Hospital, France
Timothy Lynch, The Mater Misericordiae University Hospital, Ireland
Evžen Růžička, Charles University, Czech Republic
OPTIM-PARK
Optimization of community resources and systems of support to enhance the process of living with Parkinson’s Disease: a multisectoral intervention
Coordinator:
Maria Carmen Portillo, University of Southampton, United Kingdom
Partners:
Maria Victoria Navarta, University of Navarra, Spain
Lydia López Manzanares, Hospital Universitario de la Princesa, Spain
Christina Foss, University of Oslo, Norway
Anita Haahr, VIA University College, Denmark
SHAPE
Self-management and HeAlth Promotion in Early-stage dementia with e-learning for carers – A randomised controlled trial
Coordinator:
Ingelin Testad, Stavanger University Hospital, Norway
Partners:
Geir Selbæk, Norwegian National Advisory Unit on Ageing and Health, Norway
Linda Clare, University of Exeter, United Kingdom
Martin Knapp, London School of Economics & Political Science, United Kingdom
Kaarin Anstey, University of New South Wales, Australia
SHARED
Social Health And Reserve in the Dementia patient journey
Coordinator:
Arfan Ikram, Erasmus MC Rotterdam, The Netherlands
Partners:
René Melis, Radboud UMC, The Netherlands
Anna-Karin Welmer, Karolinska Institutet, Sweden
Henry Brodaty, University of New South Wales, Australia
Daniel Davis, University College London, United Kingdom
Karin Wolf-Ostermann, University of Bremen, Germany
Joanna Rymaszewska, Wroclaw Medical University, Poland
Did you know that there are 10 JPIs (Joint Programming Initiatives) addressing societal challenges, from climate change to neurodegenerative diseases, through coordinated research and innovation in Europe? Watch the video below, created in honour of the tenth anniversary of JPIs, to find out more about how they are tackling some of the biggest issues facing our society.