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The Swedish BioFINDER Study consists of four cohorts where patients are included prospectively and followed longitudinally (www.biofinder.se). At baseline, these individuals undergo detailed and standardized cognitive, neurological and psychiatric examinations. Plasma, blood, CSF and samples for cell biology studies are collected. Most also have also undergone advanced Magnetic Resonance Imaging, and in many of the non-demented cases Amyloid and Tau positron emission tomography (PET) imaging have also been done.

The subcohorts include:
i) Healthy volunteers. Ca 350 volunteers aged 60-100 years old from the population-based Malm’ EPIC cohort (380 participants as of Feb 2016). Follow-up time: at least 8 years with investigations repeated every second year. In this cohort, appr. 20% is expected to have preclinical AD.
ii) Patients with Mild Cognitive Impairment (MCI) or Subjective Cognitive Decline (SCD). Ca 500 patients with MCI/SCD aged 60-80 years. Follow-up time: at least 6 years with investigations repeated every year. In this cohort, appr. 50% is expected to have prodromal AD.
iii) Patients with different dementia disorders. We include ca 250 dementia cases aged 40-100 years with AD, VaD, DLB, PDD or FTD. Follow-up time: at least 2 years with investigations repeated every year.
IV) Patients with Parkinson’s disease (PD) and PD-related disorders. Ca 300 patients with Parkinson-like symptoms. Follow-up time: at least 6 years with investigations repeated every year.

Last Update 21/09/2017

All people aged 65-84 listed in the population registers of the 12 Italian participating towns as resident and alive on the 31.12.2002. The community based random sample was stratified by gender and 5-year age classes following an equal allocation strategy.

The general objective of IPREA-FU is to improve the evidence base on the preclinical phase of dementia, providing a better insight into its heterogeneous evolution.

Last Update 21/09/2017

The EVA study was a 9-year longitudinal study with 6 waves of follow-ups. During the two-year period 1991-1993 (EVA0), 1389 men and women born between 1922 and 1932 were recruited.

The aim is to investigate vascular ageing, decline in brain and cognitive function and associated factors with a longitudinal follow-up study. The secondary objective is to determine to role of biological factors linked with oxidative stress and brain ageing.
Inclusion criteria Subjects from both genders born between 1922 and 1932 (59 to 71 years old at enrolment), included in electoral registers in Nantes, can speak French and living in Nantes.

Last Update 21/09/2017

The ADC was setup in 2004 by including all patients who come to the Alzheimer Center for diagnostic work up and who consent to give all data, collected as part of the routine diagnostic work up, for research. The aim is and was to facilitate research into new and existing biomarkers in the broadest sense, to establish diagnostic, prognostic and theragnostic values and further insight into the pathogenesis of neurodegenerative dementias. The data are collected on a weekly basis and consist of baseline data and annual follow up data. Since it is conception it has grown into one of the largest clinical databases in the dementia field. More info on setup, characteristics and data collection can be found in van der Flier WM, Pijnenburg YA, Prins N, Lemstra AW, Bouwman FH, Teunissen CE, van Berckel BN, Stam CJ, Barkhof F, Visser PJ, van Egmond E, Scheltens P.

Optimizing patient care and research: the Amsterdam Dementia Cohort. J Alzheimers Dis. 2014;41(1):313-27. doi: 10.3233/JAD-132306. PubMed PMID: 24614907.

Last Update 21/09/2017

The Coronary Artery Risk Development in (Young) Adults (CARDIA) Study was initiated in 1984 by the National Heart, Lung, and Blood Institute (NHLBI) to assist in providing a better understanding of the
trends and determinants of coronary heart disease (CHD) in the United States (US). The study began by focusing on young adults ? persons 18 to 30 years of age at the time of the Year 0 (Y0) baseline
screening, undertaken between March 1985 and June 1986. A random selection of 5,115 black and white men and women identified by each of the four CARDIA field centres constituted the cohort.

Follow?up examinations at Y2, Y5, Y7, Y10, Y15, Y20, and Y25 achieved high retention, collected a rich set of high quality data and stored specimens bearing on the risk factors and possible causes of cardiovascular disease (CVD).

Last Update 21/09/2017

Next Steps (previously known as the Longitudinal Study of Young People in England – LSYPE) is a major innovative cohort study of young people. The study began in 2004 and included all young people in Year 9, aged between 13 and 14, who attended state and independent schools in England.

Next Steps is one of the main information sources for the formation and appraisal of policies relating to young people and will continue to be so for at least the next 10 years. The baseline data will be used to monitor the progress of the cohort group, evaluate the success of policies aimed at this group and provide an evidence base for further policy development. The study brings together data from a wide range of sources and reflects the variety of influences on learning and progression.

Following the initial survey at age 13-14, the cohort members were visited every year until 2010, when they were age 19-20. Young people were interviewed along with their parents up to sweep 4 (age 17).

The most recent survey took place in 2015/16, when the cohort members were 25 years old. It maintained the strong focus on education, but the content was broadened to become a more multi-disciplinary research resource. Data was collected about cohort members’ housing and family life, employment and economic circumstances, education and job training, physical and emotional health, and identity and participation. A wide range of administrative data linkage consents were collected in the domains of health, education, economics and criminal behaviour.

Last Update 21/09/2017

STROKOG is a consortium of longitudinal studies of cognitive disorders following stroke, TIA or small vessel disease. Developed under the auspices of VASCOG (Society for the Study of Vascular Cognitive and Behavioural Disorders), it is the first international effort to harmonise work on post-stroke dementia and is being led by CHeBA researchers.

The consortium brings together studies that have examined post-stroke or other high vascular risk cohorts longitudinally, with cognitive decline and dementia (including sub-types) as primary outcome variables. The included studies (N=27; total sample of more than 10,000 individuals, representing 17 countries) have rich neuropsychological and MRI data, and some recent studies (n=3) have included amyloid imaging in sub-samples. A number of studies have CSF and/or plasma available for biomarker studies, and participant enrolment in brain banks for neuropathology.

Last Update 21/09/2017

General objectives of the NuAge Study:
1. To assess changes in dietary intakes of ageing men and women (foods, energy, macronutrients, micronutrients) and longterm exposure to functional foods from a qualitative and quantitative perspective;
2. To assess the influence of longstanding and current dietary habits and evolving food choices on changes in numerous markers of physical and cognitive status, functional autonomy and social functioning;
3. To assess the impact of age-related alterations in energy metabolism (utilisation and expenditure) and body composition, on changes in numerous markers of physical and cognitive status, functional autonomy and social functioning;
4. To assess the impact of individual (biological, psychological, health, functional, behavioural) and environmental determinants on dietary intakes.

The population is comprised of 1793 healthy men and women, selected from three age groups (68ﾖ72, 73ﾖ77, 78ﾖ82) at recruitment. A total of 82.4% of the population is French speaking participants and a total of 14.3% is English speaking participants.

Last Update 21/09/2017

The Australian Longitudinal Study of Ageing (ALSA) is the centrepiece research activity of the Flinders Centre for Ageing Studies. The ALSA commenced in 1992 with 2087 participants aged 65 years or more. At Baseline, a comprehensive personal interview and assessment of neuropsychological and physiological functions was undertaken at each person’s home, supplemented by self-completed questionnaires, biochemistry, and additional clinical studies of physical function. The final wave (Wave 13) of data collection was carried out in 2014.

The general purpose of the ALSA study is to gain further understanding of how social, biomedical and environmental factors are associated with age related changes in health and well-being of persons aged 70 years and over. Emphasis is given in the overall study to defining and exploring the concept of healthy, active ageing, particularly in a South Australian context.

Last Update 21/09/2017

The Irish Longitudinal Study on Ageing (TILDA) is a large-scale, nationally representative, longitudinal study on ageing in Ireland, the overarching aim of which is to make Ireland the best place in the world to grow old.
TILDA collects information on all aspects of health, economic and social circumstances from people aged 50 and over in a series of data collection waves once every two years. TILDA is unique amongst longitudinal studies in the breadth of physical, mental health and cognitive measures collected. This data, together with the extensive social and economic data, makes TILDA one of the most comprehensive research studies of its kind both in Europe and internationally.

Last Update 21/09/2017