Principal Investigators


A/Pr Daniel Hatters

Institution


University of Melbourne

Contact information of lead PI


Country


Australia

Title of project or programme


Pathogenic and adaptive molecular interactions with mutant huntingtin exon 1

Source of funding information


National Health and Medical Research Council

Total sum awarded (Euro)


€ 493,988

Start date of award


01/01/2016

Total duration of award in years


4

Keywords


Research Abstract


This project aims to determine how the gene mutation that causes Huntington’s disease (HD) damages cells in the brain. The diseased gene creates a protein that is abnormally sticky, which causes it to form clumps. Our goal is to determine the components of the cell that are disrupted and damaged as clumping happens. Understanding this link will enable therapeutics to be logically designed in efforts to prevent harm to the brain, potentially before symptoms are evident.

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