Project Cygnus

This is a feasibility study which has a Longitudinal Cohort design, following up participants at selected time points over a 1 year duration. The study will recruit 2 distinct groups: (1) patients with symptoms of cognitive impairment, and (2) study partners who are cognitively normal. The patients recruited to group 1 will have been recently referred to a Memory Assessment Service by their GP with suspected Mild Cognitive Impairment (MCI) & mild dementia. All patients referred to a Memory Assessment Service for this reason will be potentially eligible for inclusion in the study. Close friends or family members involved in looking after the cognitively impaired participants will also be asked to participate as study partners to attempt to measure the impact that looking after a partner, friend or family member with memory problems can have on a carer’s Quality of Life and other variables such as financial burden. Both cognitively impaired participants and their study partners will be given the option of additionally participating in two sub-studies:

– Mobile data collection: Using a web/mobile app to collect self-reported data on a more regular basis from home

– Wearable device: Using a wearable device that looks like a watch to collect information on activity and sleep

Types Neurodegenerative disease-specific cohort
Participant Types At-risk diagnosis
Countries United Kingdom
Genders Male and Female
Sample sizes 0 to 4,999
Ages 10 to 19|20 to 39|40 to 59|60 to 100
Brain related measures
Funtional rating Caregiver|Individual physiological|Individual psychological
Anthropometric Height|Weight
Physical Cardiovascular|Hearing and Vision|Respiratory
Biological samples
Genotyping
Brain imaging
Brain banking
Lifestyle Alcohol|Physical activity|Smoking
Socio-economic Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care
Health service utilisation Formal health and social care service utilisation including private care
Institute names IXICO PLC., University of Manchester, Northern Health Science Alliance Network (NHSA)
Current Sample Sizes 0 to 4,999

age at recruitment >18
last updated
recruitment period 1st April 2016 – 30th September 2017
estimated current sample size number value 389
cohort acronym CYGNUS
start date 1st April 2016 – 30th September 2017
pi Dr Iracema Leroi
website http://www.ecygnus.com/
contact details Project Cygnus
Genomics Research
Stopford Building
Oxford Road
Manchester
M13 9PT
abstract  To understand the patient and care-giver journeys from the initial memory assessments through the early period of treatment and care, the CYNGUS study will collect clinical data and self-reported outcomes from 500 people with memory loss and their supportive partners for one year.
funders  Innovate UK
contact email Email: [email protected]
PI Email: [email protected]
contact phone number Tel: +44 (0)161 275 1623
estimated current sample size 0 to 4,999
sample sizes 500