General Information
Rat: Sprague-Dawley
These rats express the tetracycline-controlled transactivator under a constitutive promoter (CAG-tTA) and the human LRRK2 gene tagged with HA and under the control of a tretracycline-responsive element (TRE)-fused mini-cytomegalovirus promoter. In this model, the human LRRK2 gene is expressed in the absence of tetracycline or its derivatives (e.g. Doxycycline).
Endogenous rat LRRK2 : yes
Corresponding human genotype: LRRK2 is the greatest known genetic contributor to Parkinson’s disease.
Mutated gene: hLRRK2
References: Zhou 2009
Transgene expression
- The transgene is expressed in various tissues, including the cortex, brain stem and the cerebellum.
Neurodegeneration
- Not reported
Dopamine Homeostasis
- Not reported
Inclusions
- Not reported
Motor Behaviours
- 1.5-3 months: Motor performances of the transgenic animals appear normal on the accelerating rotarod.
Response to dopaminergic treatment
- Non-applicable in the absence of motor impairment.
Non-motor Behaviours
- Not reported
Electrophysiology
- Not reported
Neuroinflammation
- Not reported