General Information

Mouse: FVB/N x 129S6/SvEvTac

Expression of the wild type human alpha-synuclein protein using the P1 artificial chromosome (PAC).

Endogenous alpha-synuclein: No

Corresponding human genotype: gene multiplication in familial PD; polymorphism in the non-coding region of the alpha-synuclein locus

Transgene insertion: 4 chromosomal insertions

References: Kuo 2010

Transgene expression

  • 6 weeks-6 months: high (40x) and stable transgene expression is dectected in whole brain and distal colon.


  • 11 and 18 months: no evident loss of TH-positive neurons is detected in the SN

Dopamine Homeostasis

  • 11 and 18 months: No deficits are observed


  • 6-18 months: no alpha-synuclein abnormalities are observed in central and enteric nervous systems

Motor Behaviours

  • No gross motor symptoms (ataxia, tremor, paralysis) are observed at any time
  • 6-18 months: no impairments are detected in the rotarod and open field tests.

Response to L-DOPA treatment

  • Not reported

Non motor Behaviours

  • Colonic deficits: no deficits are observed at any time
  • Whole-gut transit time: no deficits are observed at any time
  • Olfaction: no deficits are observed at any time
  • Autonomic dysfunctions: no deficits are observed at any time


  • Not reported.


  • Not reported.

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