General Information
Mouse: CB576J
Conditional expression of the human C-terminal-truncated (1-119) mutant (A53T) alpha-synuclein under the control of the endogenous ROSA 26 promoter in a Cre recombinase -dependent manner. Breeding with TH-Cre transgenic mice allows the selective expression of the transgene in dopaminergic neurons.
Endogenous mouse alpha synuclein: Yes.
Corresponding human genotype: The A53T mutation causes a rare autosomal dominant familial form of PD. The truncated form of alpha-synuclein detected in brain tissue from post mortem PD brain and enriched in Lewy bodies
Transgene insertion: ROSA 26 locus
References: Daher 2009
Transgene expression
- 10 months: Transgene expression is observed in TH positive neurons and/or terminals, including olfactory bulb, striatum, cerebral cortex and ventral midbrain. A low expression level of the mutant protein is observed compared to that of endogenous mouse alpha-synuclein
Neurodegeneration
- 10-12 months: No loss of TH-positive neurons is observed.
No change in survival observed up to 18 months of age.
Dopamine Homeostasis
- Not reported
Inclusions
- Not reported
Motor Behaviours
- Not reported
Response to L-DOPA treatment
- Not reported
Non motor Behaviours
- Not reported
Electrophysiology
- Not reported
Neuroinflammation
- Not reported