General Information

Mouse: Swiss Webster x CB57BL/DAB

Expression of the mutant A30P human alpha-synuclein under the control of the rat tyrosine hydroxylase (TH) promoter.

Endogenous mouse alpha synuclein: Yes.

Corresponding human genotype: Autosomal dominant mutation in PD patients (PARK1); early onset disease

Transgene insertion:  not specified

References: Matsuoka 2001

Transgene expression

• 12 months: Transgene expression is observed in the brainstem, midbrain neurons, olfactory bulb and retinal anacrine cells. High protein levels are detected in nigrostriatal dopamine neurons.

Neurodegeneration

• 12 months: No loss of TH-positive neurons is observed.

Dopamine Homeostasis

• No changes observed

Inclusions

• 12 months: no inclusions are detected

Motor Behaviours

• Not reported

Response to L-DOPA treatment

• Not reported

Non motor Behaviours

• Not reported

Electrophysiology

• Not reported

Neuroinflammation

• Not reported