General Information
Mouse: CB57BL/CH3
Expression of the wild type human alpha-synuclein protein under the control of the mouse Prion Protein (PrP) gene promoter
Endogenous mouse alpha synuclein: Yes
Corresponding human genotype: gene multiplication in familial PD; polymorphism in the noncoding region of the alpha-synuclein locus
Transgene insertion: not specified
References: Giasson 2002
Transgene expression
- 3 months: expression of transgene is observed in the cortex, cerebellum, midbrain and spinal cord.
Neurodegeneration
- no loss of TH-positive neurons is observed
Dopamine Homeostasis
- Not reported
Inclusions
- 26 months: no inclusions are observed
Motor Behaviours
- Up to 28 months: not motor phenotype is observed.
Response to L-DOPA treatment
- Not reported
Non motor Behaviours
- Not reported
Electrophysiology
- Not reported
Neuroinflammation
- Not reported