General Information
Mouse: C57BL6/J
Mice in which exons 2 and 3 of the DJ-1 gene were deleted leading to the absence of DJ-1 protein in homozygous DJ-1-/- mice. Male and female mice are fertile, show no changes in weight gain compared to wt mice, and comparable life span.
Endogenous DJ-1: No
Corresponding human genotype: Autosomal recessive genetic deletion in the DJ-1 gene causing a loss-of-function of the protein and leading to early-onset Parkinson’s disease (PARK7).
Mutated gene: DJ-1
References: Andres-Mateos 2007
Neurodegeneration
- 2-3 and 18-24 months: No apparent changes in the number TH-positive neurons
Dopamine Homeostasis
- 2-3 and 18-24 months: No apparent changes DA and DA metabolites levels are observed
Inclusions
- Not reported
Motor Behaviours
- 2-3 and 18-24 months: No changes spontaneous horizontal and vertical locomotion (open field test) are observed
Response to dopaminergic treatment
- Not reported.
Non motor Behaviours
- Not reported.
Electrophysiology
- Not reported.
Neuroinflammation
- Not reported
Updated 25/04/2018