General Information
Mouse: C57BL/6 x 129/Sv
Mice with triple deletion of the Parkin, PINK1 and DJ-1 genes. Mice are viable and fertile without any obvious abnormalities.
Corresponding human genotype: No equivalent triple gene mutations have been described in patients with Parkinson’s disease. Autosomal recessive mutation in the PINK1 gene leading the early-onset Parkinson’s disease.
Mutated gene: PINK1, Parkin and DJ-1
References: Kitada 2009
Neurodegeneration
- 3, 16 and 24 months: normal morphology and no loss of TH-positive neurons are observed in the SN. No differences are observed in noradrenergic neurons in the locus coeruleus
Dopamine Homeostasis
- 16 months: no changes in the levels of dopamine and dopamine metabolites are observed in the striatum.
- 24 months: a significant increase in dopamine levels is detected.
Inclusions
- Not reported
Motor Behaviours
- Not reported
Response to dopaminergic treatment
- Not reported
Non motor Behaviours
- Not reported
Electrophysiology
- Not reported
Neuroinflammation
- Not reported