General Information

Mouse: Swiss Webster x CB57BL/DAB

Expression of the mutant A53T human alpha-synuclein under the control of the rat tyrosine hydroxylase (TH) promoter.

Endogenous mouse alpha synuclein: Yes.

Corresponding human genotype: Autosomal dominant mutation in PD patients (PARK1); early onset disease

Transgene insertion:  not specified

References: Matusoka 2001; Manning-Bog 2003

Transgene expression

  • 12 months: Transgene expression is observed in the brainstem, midbrain neurons, olfactory bulb and retinal anacrine cells. High protein levels are detected in nigrostriatal dopamine neurons.


  • 12 months: No loss of TH-positive neurons is observed. Reduced sensitivity to paraquat toxicity is detected.

Dopamine Homeostasis

  • No changes observed


  • 12 months: no inclusions are detected

Motor Behaviours

  • Not reported

Response to L-DOPA treatment

  • Not reported

Non motor Behaviours

  • Not reported


  • Not reported


  • Not reported

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