The Moli-sani study (www.moli-sani.org) is a cohort study aiming at evaluating the risk factors (environmental, genetics, bio-molecular) linked to chronic-degenerative disease with particular regard to cancer, cardiovascular, cerebrovascular and neurodegenerative disease.
The study has recruited, between March 2005 and April 2010, 24,325 people aged ³ 35 living in the Molise region, from city hall registries by a multistage sampling. Exclusion criteria were pregnancy at the time of recruitment, disturbances in understanding or willingness, current poly-traumas or coma, or refusal to sign the informed consent. Participation rate was 70%.
All subjects underwent electrocardiogram and spirometric tests aimed to evaluate pulmonary diffusion capacity, gas diffusion and pulmonary volumes through plethysmography.
The European Prospective Investigation into Cancer and Nutrition FFQ was used to determine daily nutritional intakes consumed in the past year.
A follow-up based on linkage with hospital discharge records (SDO) and mortality regional registry was performed at December 2011 with a median of 4.3 years and at December 2014 with a median of 9.6 years. Outcomes analysed at follow-up are: mortality for any and specific causes, hospitalization and hospital stay, coronary artery disease, stroke, atrial fibrillation, heart failure, diabetes, cancer.
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UK Biobank is a major national health resource, and a registered charity in its own right, with the aim of improving the prevention, diagnosis and treatment of a wide range of serious and life-threatening illnesses including cancer, heart diseases, stroke, diabetes, arthritis, osteoporosis, eye disorders, depression and forms of dementia.
500,000 people aged between 40-69 years were recruited in 2006-2010 from across the country to take part in this project. They have undergone measures, provided blood, urine and saliva samples for future analysis, detailed information about themselves and agreed to have their health followed. The cohort is primarily followed through data linkage but the cohort was re-contacted in 2012-13 with a further 100,000 to be approached over the next few years.
The Whitehall II Study was established in 1985 to investigate the importance of socioeconomic circumstances for health by following a cohort of working men and women aged 35-55 at enrolment. Participants have taken part in twelve data collection phases, seven of which have included a medical screening. The aim of the study is to understand the causes of age-related heterogeneity in health.
By combining the existing 30 years of data on social circumstances, risk factors and chronic disease with new clinical measures of cognitive function, mental disorders and physical functioning, Whitehall II has been transformed interdisciplinary study of ageing. In addition to providing insights into individual and social differences in the development of frailty, disability, dependence, and dementia, the study helps in the determination of optimal time windows and targets for interventions that maximise the potential for healthy-ageing and independent living.
On 1st June 1932, as part of the Scottish Mental Survey, 87,498 Scottish schoolchildren born in 1921 sat the same test of mental ability: the Moray House Test. In 1997, the Universities of Aberdeen and Edinburgh began to search for men and women still living in Scotland who took part in these tests.
On 1st June 1998, about 80 individuals gathered in the Aberdeen Music Hall to re-sit the test exactly 66 years later. Participants were followed-up 5 times over a 10 year period.
Aberdeen University has followed all of the children born in Aberdeen in 1921, 1936 (see Aberdeen Birth Cohort 1936) and 1950-1956 (see Aberdeen Children of the 1950s) as they grow and age.
Collectively these groups are known as the ABERDEEN BIRTH COHORTS, and have helped to advance our understanding of aging well.
Over the years, researchers have linked the results from these tests to health and social information.
The linked data has been used to answer questions like:
Does being born very small affect mental health later in life?
Is the risk of dementia related to childhood intelligence?
What influences quality of life in old-age?
Participants born in 1921 and 1936 have been invited back for a wide variety of studies at the University. Similar research is being started for the Children of the 1950’s group.
On 4th June 1947, as part of the Scottish Mental Survey, every Scottish schoolchild born in 1936 sat the same test of mental ability: the Moray House Test. In 1997, Professor Lawrence Whalley discovered the Scottish Mental Survey test records at the Scottish Council for Research in Education in Edinburgh and began to trace people who had sat the test in Aberdeen.
Aberdeen University has followed all of the children born in Aberdeen in 1921, 1936 (see Aberdeen Birth Cohort 1936) and 1950-1956 (see Aberdeen Children of the 1950s) as they grow and age.
Collectively these groups are known as the ABERDEEN BIRTH COHORTS, and have helped to advance our understanding of aging well.
Over the years, researchers have linked the results from these tests to health and social information.
The linked data has been used to answer questions like:
Does being born very small affect mental health later in life?
Is the risk of dementia related to childhood intelligence?
What influences quality of life in old-age?
Participants born in 1921 and 1936 have been invited back for a wide variety of studies at the University. Similar research is being started for the Children of the 1950’s group.
The health of the agricultural population has been previously explored, particularly in relation to the farming exposures and among professionally active individuals. However, few studies specifically focused on health and aging among elders retired from agriculture. Yet, this population faces the long-term effects of occupational exposures and multiple difficulties related to living and aging in rural area (limited access to shops, services, and practitioners). However, these difficulties may be counter-balanced by advantages related to healthier lifestyle, richer social support and better living environment. The general aim of the AMI cohort was to study health and aging in elderly farmers living in rural area through a multidisciplinary approach, with a main focus on dementia.
The study started in 2007, with two follow-up visits over 5 years. Baseline visits were conducted at home by a neuropsychologist then by a geriatrician for all cases suspected of dementia, for all subjects suspected of being demented. The 10-year visit is currently on going.
The British Women’s Heart and Health Study is a prospective cohort study of heart disease in over 4000 British women between the ages of 60 and 79. It is funded by the British Heart Foundation. The Study aims to provide information about existing patterns of treatment of heart disease, and further the understanding of risk factors and disease prevention. We collected our baseline data in 1999-2001, and have been tracking the cohort since. Participants have been re-contacted through questionnaires or assessment in 2003, 2007 & 2010.
The aim of the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) project is to identify the neural mechanisms underpinning successful cognitive ageing. The study recruitment participants over 18 from resident within Cambridge City and used epidemiological, behavioural, and neuroimaging data to understand how individuals can best retain cognitive abilities into old age. A major aim of the research programme is to understand the nature of brain-cognition relationships across the lifespan, and to highlight the importance of abilities that are maintained into old age.
This population study was not designed to have repeated measures for each participant, but rather as one extended and comprehensive study visit that took place over 3 stages.
The Costa Rican Longevity and Healthy Aging Study (CRELES) is a nationally representative longitudinal survey of health and lifecourse experiences of 2,827 Costa Ricans ages 60 and over in 2005. Baseline household interviews were conducted between November 2004 and September 2006, with 2-year follow-up interviews.
The main study objective was to determine the length and quality of life, and its contributing factors in the elderly of Costa Rica.
CRELES uses public data files containing information on a broad range of topics including self-reported physical health, psychological health, living conditions, health behaviours, health care utilization, social support, and socioeconomic status. Objective health indicators include anthropometrics, observed mobility, and biomarkers from fasting blood and overnight urine. Mortality events are tracked and conditions surrounding death are measured in a surviving family interview (longitudinal follow-up data are not yet publicly available).
This is a feasibility study which has a Longitudinal Cohort design, following up participants at selected time points over a 1 year duration. The study will recruit 2 distinct groups: (1) patients with symptoms of cognitive impairment, and (2) study partners who are cognitively normal. The patients recruited to group 1 will have been recently referred to a Memory Assessment Service by their GP with suspected Mild Cognitive Impairment (MCI) & mild dementia. All patients referred to a Memory Assessment Service for this reason will be potentially eligible for inclusion in the study. Close friends or family members involved in looking after the cognitively impaired participants will also be asked to participate as study partners to attempt to measure the impact that looking after a partner, friend or family member with memory problems can have on a carers Quality of Life and other variables such as financial burden. Both cognitively impaired participants and their study partners will be given the option of additionally participating in two sub-studies:
Mobile data collection: Using a web/mobile app to collect self-reported data on a more regular basis from home
Wearable device: Using a wearable device that looks like a watch to collect information on activity and sleep