The longitudinal Study of Cognitive Change in Normal Healthy Old Age (LSCC) is a population study including 6,342 healthy residence of Greater Manchester and Newcastle-upon-Tyne aged from 42 to 92 in 1983. Two different batteries of cognitive tests were alternately administered biennially with additional questionnaires and Dna sample collection until 2003. The aims of the study were to:

• to determine sources of variations in rates of cognitive change between individuals
• to identify factors that slow or accelerate cognitive ageing and that prolong mental productivity or accelerate decline
• to generate and test functional models for the processes of biological ageing, especially of ageing of the brain and the central nervous system
• to test whether the neurophysiological and consequent cognitive changes differ in idiosyncratic patterns between individuals

The Health Survey for England series was designed to monitor trends in the nation’s health, to estimate the proportion of people in England who have specified health conditions, and to estimate the prevalence of risk factors associated with these conditions. The surveys provide regular information that cannot be obtained from other sources on a range of aspects concerning the public’s health. The surveys have been carried out since 1994 by the Joint Health Surveys Unit of NatCen Social Research and the Research Department of Epidemiology and Public Health at UCL. Individuals are asked for written consent to link their HSE records to mortality and cancer registration data (from HSE 1994 onwards) and to Hospital Episodes Statistics (from HSE 2003 participants onwards).

Each survey in the series includes core questions and measurements (such as blood pressure, height and weight, and analysis of blood and saliva samples), as well as modules of questions on topics that vary from year to year. New topics in 2014 year included hearing and mental health. The achieved sample for the 2014 survey was 8,077 adults (aged 16 and over) and 2,003 children (aged 0-15).

For the Esprit study, 1863 non-institutionalized persons aged 65 years and over were randomly recruited in 1999 from the Montpellier district electoral rolls, and re-examined 6-times at 2-3 yearly intervals. Objectives:

1) To determine current and lifetime prevalence as well as incidence of psychiatric disorder in the elderly;
2) to determine the risk factors for these disorders, their relative weight and interactions;
3) to study clinical heterogeneity;
4) to estimate the probability of transition towards a subsyndromic state or a given pathology;
5) to elaborate predictive etiological models.

The aim of the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) project is to identify the neural mechanisms underpinning successful cognitive ageing. The study recruitment participants over 18 from resident within Cambridge City and used epidemiological, behavioural, and neuroimaging data to understand how individuals can best retain cognitive abilities into old age. A major aim of the research programme is to understand the nature of brain-cognition relationships across the lifespan, and to highlight the importance of abilities that are maintained into old age.

This population study was not designed to have repeated measures for each participant, but rather as one extended and comprehensive study visit that took place over 3 stages.

The Health 2000 Survey, carried out in 2000-2001 in Finland, was coordinated by the National Institute for Health and Welfare, THL (the former National Public Health Institute) in co-operation with an extensive network of organizations and experts. The aim of the survey was to provide information on major public health problems, their causes and treatment, health service needs and utilization as well as functional and working capacity. The data for the survey were collected in comprehensive health examination including blood sampling, in interviews and in self-administered questionnaires. The nationally representative sample included 8,028 persons aged 30 or over of whom 85% participated in the health examination conducted at 80 areas in the mainland Finland. In addition, 1,894 young adults (18-29 years) were invited to the health interview and fill in the questionnaire. Further, 1,278 people who had taken part in Mini-Finland Health Survey carried out in 1978-1980 were invited to the re-examination.

The follow-up of the Health 2000 Survey, the Health 2011 Survey, was carried out in 2011-2012. All members of the Health 2000 sample (n=8,135), who were living in Finland in 2011 and had not refused requests to be invited to further studies, were invited to the Health 2011 Survey. In 2011, they were at least 29 years of age. A total of 59% of them participated in the health examination conducted at 59 areas in Finland. In addition, a new random sample of young adults (aged 18-28, n=1,994) was taken. A total of 415 of them were invited to the health examination and the rest of them (1,579) received only the postal questionnaire. Further, 920 people who had previously taken part in the Mini-Finland Health Survey and invited to re-examination in 2001 were invited.

The Health 2000/2011 cohort is also continuously followed-up by linkage to Finnish nationwide registers.

The CARTaGENE (CaG) study is both a population-based biobank and the largest ongoing prospective health study of men and women in Quebec. CaG targeted the segment of the population that is most at risk of developing chronic disorders, that is 40-69 years of age, from six census metropolitan areas in Quebec. The sampling was stratified by age, sex and postal groups and is proportional to the density of the population in these areas. Over 43,000 participants consented to visiting 1 of 12 assessment sites where detailed health and socio-demographic information, physiological measures and biological samples (blood, serum and urine) were captured. Participants are followed-up based on linkage to governmental health administrative databases and direct reassessment through a web portal.

Last update 21/09/2017

KORA stands for “Kooperative Gesundheitsforschung in der Region Augsburg” (Cooperative Health Research in the Augsburg Region). KORA studies are conducted at regular intervals in order to assess the health status of the population in Augsburg and the surrounding area since 1984. The extensive database and biological specimen repository provide an excellent platform for national and international health research. More than 200 research projects a year are conducted with regional, national and international partners. To date, more than 2,000 publications have been issued. The main research areas are:
– Lifestyle and environmental factors as risk factors in the development of chronic diseases
– Identifying new genes for the most important chronic diseases and related risk factors
– Integrating research into risk factors and functional genomics
– Research on health systems: usage, costs and health status

Last Update 21/09/2017

Alberta’s Tomorrow Project (ATP) is a longitudinal study tracking the health of 55,000 adults aged 35-69 years in this western Canadian province. ATP was launched in 2000 as a prospective cohort research platform to study the relationship between environmental, lifestyle, and genetic factors and the incidence of cancer and chronic diseases.

In 2008, ATP joined a nation-wide research platform called the Canadian Partnership for Tomorrow Project (CPTP) representing more than 300,000 participants from five provincial cohorts: Alberta, British Columbia, Ontario, Quebec and the Atlantic provinces (Prince Edward Island, New Brunswick, Newfoundland and Labrador, and Nova Scotia). Together, the consortium of five regional studies provides greater statistical power for research, as well as opportunities to examine geographical trends in health and wellbeing across Canada’s vast landscape.

The information contained herein is specific to the ATP cohort.

Last Update 21/09/2017

The Wisconsin Longitudinal Study (WLS) is a longitudinal population cohort started in 1957, with a questionnaire administered to all Wisconsin High School seniors. In 1964, a randomly selected one-third of the members of the class of 1957 were followed up with a brief questionnaire to parents asking about their child’s post high-school education and occupation. Direct contact with the graduate began with a telephone interview in 1975, and subsequent telephone and mail surveys in 1993 2004. In 1977 a subset of graduate’s siblings were interviewed by phone and in 1995 and 2005 interviews were conducted with one sibling from each family whenever possible. Spouses of Graduates and Siblings who were married at the time of the 2004/2005 interview were also interviewed by phone. Most recently in-person interviews with a leave-behind questionnaire were administered in 2011 to both the graduate and sibling panels. Saliva was collected from both graduate and sibling participants via a mail-effort in 2008 and during the in-person 2011 interview.

Last Update 21/09/2017 

General objectives of the NuAge Study:
1. To assess changes in dietary intakes of ageing men and women (foods, energy, macronutrients, micronutrients) and longterm exposure to functional foods from a qualitative and quantitative perspective;
2. To assess the influence of longstanding and current dietary habits and evolving food choices on changes in numerous markers of physical and cognitive status, functional autonomy and social functioning;
3. To assess the impact of age-related alterations in energy metabolism (utilisation and expenditure) and body composition, on changes in numerous markers of physical and cognitive status, functional autonomy and social functioning;
4. To assess the impact of individual (biological, psychological, health, functional, behavioural) and environmental determinants on dietary intakes.

The population is comprised of 1793 healthy men and women, selected from three age groups (68ヨ72, 73ヨ77, 78ヨ82) at recruitment. A total of 82.4% of the population is French speaking participants and a total of 14.3% is English speaking participants.

Last Update 21/09/2017