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The Coronary Artery Risk Development in (Young) Adults (CARDIA) Study was initiated in 1984 by the National Heart, Lung, and Blood Institute (NHLBI) to assist in providing a better understanding of the
trends and determinants of coronary heart disease (CHD) in the United States (US). The study began by focusing on young adults ? persons 18 to 30 years of age at the time of the Year 0 (Y0) baseline
screening, undertaken between March 1985 and June 1986. A random selection of 5,115 black and white men and women identified by each of the four CARDIA field centres constituted the cohort.

Follow?up examinations at Y2, Y5, Y7, Y10, Y15, Y20, and Y25 achieved high retention, collected a rich set of high quality data and stored specimens bearing on the risk factors and possible causes of cardiovascular disease (CVD).

Last Update 21/09/2017

Between 1998 and 2002 the Survey team interviewed over 12,583 Southampton women aged 20 to 34 years. Those who became pregnant after interview were invited to take part in the pregnancy phase of the survey. Women received ultrasound scans at 11, 19 and 34 weeks of pregnancy, and their babies were measured soon after birth. There were 3,158 babies born to women in the study between 1998 and 2007. The survey has followed up these children with home visits at six months, one year, two and three years. A sample of over 1,000 children was seen at 4 years of age, more than 2,000 children at ages 6-7 years, and more than 1,000 at 8-9 years. Current follow-up of children at 11-13 years will continue for a number of years.

The aim is to learn more about the dietary,lifestyle, hormonal and omic factors that influence the health of women and their children.

Last Update 21/09/2017

General objectives of the NuAge Study:
1. To assess changes in dietary intakes of ageing men and women (foods, energy, macronutrients, micronutrients) and longterm exposure to functional foods from a qualitative and quantitative perspective;
2. To assess the influence of longstanding and current dietary habits and evolving food choices on changes in numerous markers of physical and cognitive status, functional autonomy and social functioning;
3. To assess the impact of age-related alterations in energy metabolism (utilisation and expenditure) and body composition, on changes in numerous markers of physical and cognitive status, functional autonomy and social functioning;
4. To assess the impact of individual (biological, psychological, health, functional, behavioural) and environmental determinants on dietary intakes.

The population is comprised of 1793 healthy men and women, selected from three age groups (68ﾖ72, 73ﾖ77, 78ﾖ82) at recruitment. A total of 82.4% of the population is French speaking participants and a total of 14.3% is English speaking participants.

Last Update 21/09/2017

KORA stands for “Kooperative Gesundheitsforschung in der Region Augsburg” (Cooperative Health Research in the Augsburg Region). KORA studies are conducted at regular intervals in order to assess the health status of the population in Augsburg and the surrounding area since 1984. The extensive database and biological specimen repository provide an excellent platform for national and international health research. More than 200 research projects a year are conducted with regional, national and international partners. To date, more than 2,000 publications have been issued. The main research areas are:
– Lifestyle and environmental factors as risk factors in the development of chronic diseases
– Identifying new genes for the most important chronic diseases and related risk factors
– Integrating research into risk factors and functional genomics
– Research on health systems: usage, costs and health status

Last Update 21/09/2017

AIBL is a study of over 2,000 people assessed over a long period of time (over 10 years) to determine which biomarkers, cognitive characteristics, and health and lifestyle factors determine subsequent development of symptomatic Alzheimer’s Disease (AD).

The baseline inception cohort consisted of:
i. 211 individuals with AD as defined by NINCDS-ADRDA (McKhann et al, 1984);
ii. 133 individuals with Mild Cognitive Impairment (MCI)
iii. 768 healthy individuals without cognitive impairment. This group included volunteers with at least one copy of the ApoE ?4 allele, volunteers without a copy of the ApoE ?4 allele and 396 volunteers who expressed subjective concern about their memory function.

The enrichment cohort consists of:
i. 142 individuals with AD
ii. 220 individuals with MCI
iii. 582 individuals with without cognitive impairment.

The data was collected through clinics and questionnaires.

Last Update 21/09/2017

BiB – Children
Recruitment Period: 2007-11
Sample size at start or planned sample size if still recruiting: 13,857
Estimated current sample size: 13,500
Age at recruitment: 0

BiB – Mothers
Start date: 2006-10
Sample size at start or planned sample size if still recruiting: 12,453
Estimated current sample size: 12,000
Age at recruitment: 15-49

BiB – Fathers
Start date: 2006-10
Sample size at start or planned sample size if still recruiting: 3,414
Estimated current sample size: 3,000
Age at recruitment: 16-60

Born in Bradford is a long term study of a population cohort of 13,500 children, born at Bradford Royal Infirmary between March 2007 and December 2010, whose health is being tracked from pregnancy through childhood and into adult life. The information collected from the BiB families is being used to find the causes of common childhood illnesses and to explore the mental and social development of this new generation.

The Born in Bradford cohort study offers a unique window of opportunity to initiate an innovative and multidisciplinary programme of research. By recruiting pregnant women, their partners and their newborn babies to the cohort, this study offers the potential to:

  • assess the determinants of childhood and adult disease
  • assess the impact of migration
  • explore the influences of pregnancy and childbirth on subsequent health
  • generate and test hypotheses that have the potential to improve health for some of the most disadvantaged within our society.

The Bradford community provides a unique setting for a birth cohort study exploring the determinants of childhood and adult disease because of its diversity of population and high levels of ill-health.

Last Update 21/09/2017

For 30 years (since 1987) tracks the health of a group of randomly selected adult Dutch inhabitants of Doetinchem from originally between 20-60 years. This provides a wealth of information of four generations: 20-29, 30-39, 40-49 and 50-60 year olds. The name of this study is the Doetinchem Cohort Study. Every five years the health and habits of the participants are examined at the local health department.

The purpose of the Doetinchem Cohort Study is to give insight into trends in lifestyle and health. So there will be more and more knowledge about why some people age without many problems, while others have health problems at an early age. The study collects data on:

  • Lifestyle habits: exercise, diet, smoking, alcohol consumption;
  • Biological factors: blood pressure, cholesterol, (over) weight;
  • Several specific diseases: cardiovascular disease, asthma, COPD , diabetes, cancer, migraine, musculoskeletal;
  • Quality of life: cognitive functioning, social participation, psychosocial aspects of health.

The Rhineland Study is a prospective cohort study, which began in March 2016. It will include up to 30,000 participants from Bonn and asses their physical and mental health over their lifespan. The study is scheduled to run for decades and participants will be re-examined every 3-4 years.

As neurodegenerative diseases and their pathologies develop over a long time before first symptoms start to show, the Rhineland Study will include men and women aged 30 years and above regardless of their health status.
The main aims of the study are:

1. To investigate modifiable and non-modifiable causes of neurodegenerative and neuropsychiatric diseases
2. To find biomarkers/(multimodal) biomarker profiles to identify individuals at risk for neurodegenerative or neuropsychiatric disease, who might benefit from preventive interventions
3. To investigate (patho)physiology over the adult life course, with specific emphasis on brain-related outcomes.

Last Update 21/09/2017

The CLSA will collect information on the changing biological, medical, psychological, social, lifestyle and economic aspects of people’s lives across Canada. These factors will be studied to understand how, individually and in combination, they have an impact in both maintaining health and in the development of disease and disability as people age

A total of 21,241 people from across Canada have agreed to take part in a telephone interview, once every three years.

An additional 30,097 people consented to participate in an in-home interview, and a visit to one of 11 Data Collection Sites across Canada where they take part in a range of physical assessments.

These participants were selected randomly, and were aged 45 to 85 when first contacted. The interviews and visits will take place once every three years over the 20-year course of the study

The study has entered its next phase where each individual recruited between 2010 and 2015 (baseline) will be re-contacted for the first follow-up. This will be conducted between 2015 and 2018. During this phase, the CLSA research team will collect the same type of information that was collected at baseline, along with several new measures that have been introduced.

Last update – 12/05/2017

The Southall And Brent Revisited Study (SABRE) is the largest tri-ethnic population-based cohort in the UK, involving nearly 5000 European, Indian Asian and African Caribbean men and women. It investigates the causes of diabetes and disorders of the heart and circulation and examines underlying reasons for ethnic differences in risk of these disorders.

The participants were aged 40-69 when first studied between 1989 and 1991. In 2008-2011 a comprehensive combined morbidity and mortality follow up was carried out, together with non-invasive clinical measurements in order to quantify sub-clinical disease. SABRE visit 2 tested hypotheses generated from the Southall and Brent baseline studies and ongoing mortality follow-up.

SABRE Visit 3 (25 year follow-up visit) started in July 2014 and is collecting data on index participants and new participants, including partners of index participants. The focus of this visit is on cardiac, cognitive and physical function in older age, in association with mid-life risk factors. Ethnic and gender differences in function will also be examined.

Last update – 10/04/2017