The Lc65+ project is a longitudinal population-based study focusing on the development of frailty after the age of 65. The main methods in the Lc65+ study are:

ユ long term observation of subjects, beginning at 65 to 70 years, an age when frailty is still unusual, in order to study its initiation and development;
ユ prospective data collection on a large range of health dimensions, including psycho-social characteristics, in order to investigate the temporal sequence linking frailty, its risk factors, modulators, and outcomes:
ユ a population approach considering frailty as a central parameter of health in ageing populations that is useful not only for surveillance, but also for the evaluation of preventive interventions.

Follow-up is based on a yearly questionnaire sent by mail to the participant’s home. In addition, subjects are invited to the study center every three years for an interview and examination similar to those performed at baseline. The follow-up is unlimited in time and is not interrupted in the case of nursing home admission.

Last Update 21/09/2017

The major goals of this prospective cohort study of a randomly selected community sample are to: establish the prevalence and genetic, metabolic and environmental determinants of psychiatric disorders, cardiovascular risk factors (CVRF) and cardiovascular diseases (CVD) in the general population of the city of Lausanne; assess the mechanisms of the association between psychiatric disorders and CVRF / CVD.
Additional scientific questions focus on:

  • the identification of risk factors for the incidence and course of CVRF and psychiatric disorders;
    the identification of risk factors for cognitive impairment;
  • the testing of novel biological marker candidates and the incidence or course of CVRF/CVD or psychiatric disorders;
  • the testing of associations between brain anatomy patterns and CVRF and psychiatric disorders.

Last update: 19/12/2016