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The Gipuzkoa Alzheimer Project (PGA) is a longitudinal study on pre-clinical Alzheimer’s disease. This study aims to investigate the prevalence, clinical, cognitive and neuroimaging features and potential risk factors related to cardiovascular health and lifestyles for pre-clinical AD in asymptomatic (or very mildly symtopmatic, e.g. SCD) subjects from the community.

Follow-up Scheduled every 3 years for a minimum of 12 years. The first 3-year follow-up was completed in June 2015. The loss of subjects in the follow up was 9 %. 80% of people who donated cerebrospinal fluid at the baseline visit did the same in this follow-up visit. Second follow-up visit (6 yrs) to be started in April 2017.

Last update: 16/01/2017

CFAS II based in England and Wales started in 2008, and builds on the design and infrastructure of original CFAS. It has provided data on generational and geographical differences including people in institutions. It will also provide important base-line information on older people aged 65-84 in 2007-2008 who will reach the age of greatest frailty during the 2020s when the peak in the number of people aged 85 or over is expected and at a time when major therapeutic interventions for dementia could be expected to have an effect. Participants were followed up by interview throughout 2010-2011.

CFAS II is part of the Dementias Platform UK (DPUK), a multi-million pound public-private partnership to accelerate progress in dementias research http://www.mrc.ac.uk/research/facilities/dementias-platform-uk/

Last update: 13/01/2017

MRC CFAS study started in the late 1980s with the initial aim of investigating dementia and cognitive decline in a representative sample of more than 18,000 people aged over 65 years. To date there have been in the region of 48,000 interviews with participants in the study. The range of information collected has also allowed the study to investigate depression and physical disability in the older population and also look at healthy active life expectancy. Following baseline interviews, subsets of the cohort have been contacted for 1, 2, 6 and 8 year follow up and the whole sample were contacted for a 10 year follow up. There have also been in excess of 580 donations of participant’s brains after death.

CFAS is part of the Dementias Platform UK (DPUK), a multi-million pound public-private partnership to accelerate progress in dementias research http://www.mrc.ac.uk/research/facilities/dementias-platform-uk/

There is a sister study CFAS II which builds on the design and infrastructure of MRC CFAS. It has provided data on generational and geographical differences including people in institutions. CFAS I is the original three sites (Cambridge, Newcastle and Nottingham) from MRC CFAS which are used as a comparitor for CFAS II.

Last update: 13/01/2017